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Larry Di Fabrizio

  • PROFESSOR Medicine, Pulmonary, Critical Care and Sleep Medicine
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  • Sleep Medicine

  • Critical Care Medicine

  • Pulmonary Disease

  • American Board of Internal Medicine


  • MD, Washington University

  • BA, Columbia College

  • MD, Washington University

  • Residency, Internal Medicine
    Brigham and Women's Hospital, Harvard Medical School

  • Fellowship, Pulm & Critical Care
    Brigham and Women's Hospital, Harvard Medical School


    Dr. Larry Di Fabrizio has joined Mount Sinai on July 2, 2012 as the Director of the Pulmonary Faculty Practice and Associate Professor in the Department of Medicine in the Division of Pulmonary, Critical Care & Sleep Medicine.  He is a seasoned clinician with a strong academic background with more than two decades of private practice in NYC while also serving as a fellowship training Program Director for over a decade, most recently at Lenox Hill Hospital and previously at St. Vincent’s Hospital.

    Dr. Di Fabrizio’s goal at Mount Sinai is to translate cutting edge scientific breakthroughs into clinical practice.

    Dr. Di Fabrizio, a graduate of Columbia College, received his medical degree with distinction from Washington University in St. Louis. He interned and served as a medical resident and fellow in Pulmonary and Critical Care Medicine at the Brigham and Women’s Hospital, at Harvard Medical School.

    During his medical school years, he worked as a visiting student at Mount Sinai Hospital in the laboratory of Dr. James Holland, the Director of Neoplastic Diseases, and later spent a year conducting research at the Dana-Farber Cancer Center. After his clinical training, he joined the laboratory of Dr. Leonard Chess at Columbia University under a Research Fellowship in Cellular Immunology. Dr. Di Fabrizio received the American Lung Association and Howard Hughes Fellowship Training Grants and subsequently joined the full-time faculty at Columbia Medical School in the Division of Pulmonary and Critical Care Medicine. 

    In 1991 Dr. Di Fabrizio was recruited to become the Associate Chief of Pulmonary Medicine, Program Director of the Pulmonary Fellowship and Director of the Pulmonary Function and Sleep Laboratories at St. Vincent’s Medical Center in New York City.  Working in collaboration with the Department of Nuclear Medicine, he studied diagnostic strategies for pulmonary HIV disorders. He also served on St. Vincent’s TB Task Force during the height of the multi-drug-resistant TB epidemic.

    In 1996 Dr. Di Fabrizio joined Lenox Hill Hospital as the Associate Chief of Pulmonary Medicine and Associate Training Program Director and was appointed the Program Director of the Pulmonary Fellowship in 2006. Under his leadership, the Pulmonary Training Fellowship Program received commendations from the ACGME for the comprehensive curriculum manual developed by Dr. Di Fabrizio, and in 2011 the program was expanded and converted to a combined Pulmonary-Critical Care Fellowship Program.   At Lenox Hill, he served on the Critical Care Task Force which modernized the Intensive Care Units.  He also served on the Hospital Investigational Review Board and Department of Medicine Quality Improvement Committees. As a recognized leader he developed a large private clinical practice and was elected by the medical staff to the hospital’s Medical Board representing the Physician Attending Association.


  • 2011 -
    New York Times Magazine Super Doctor

  • 2011 -
    Castle Connolly Top Doctors

  • 2011 -
    US News & World Report

  • 2010 -
    Patient Choice Award

  • 1999 -
    Kiryas Joel Medical Devotion Award

  • 1990 -
    Howard Hughes Research Training Fellowship Award

  • 1990 -
    Research Training Fellowship Award
    American Lung Association

  • 1984 -
    Mosby Book Award for General Academic Exellence
    Alpha Omega Aplha


Research interests

Dr. Di Fabrizio’s research interests include evaluation of dyspnea (shortness of breathe), COPD, and postoperative cardiac care. He has extensive experience in the care of patients with cardiovascular disease and developed expertise in care and management of pre and post-operative cardiac surgical patients.  He recently served as program manager for New York Empire State education grant on postoperative pulmonary complications of thoracic aortic surgery patients. Over the last few years, Dr. Di Fabrizio has focused on quality improvement and patient safety issues, including the development of clinical pathways to prevent self-extubations in ICU, adherence to COPD guidelines and studies on the appropriate utilization and cost analysis of noninvasive ventilation.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Di Fabrizio did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Insurance Information

Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).

Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.

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