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Lan Zhou

  • ASSOCIATE PROFESSOR Neurology
  • ASSOCIATE PROFESSOR Pathology
  • ASSOCIATE PROFESSOR Neurosurgery
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Specialty

Certifications

  • Neuromuscular Medicine

  • Neurology, American Board of Psychiatry and Neurology

Clinical Focus

Education

  • M.D., Fudan University Shanghai Medical College

  • Ph.D., University of Cincinnati

  • Internship, Internal Medicine
    Wayne State University

  • Residency, Neurology
    Wayne State University

  • Fellowship, Neuromuscular
    Johns Hopkins Hospital

Biography

    Dr. Lan Zhou is an associate professor in the Department of Neurology at Mount Sinai.  She is board certified in Neurology, Neuromuscular Medicine, and Neuromuscular Pathology.  She predominantly treats adult patients with neuromuscular disorders with a special interest in myopathies and small fiber neuropathy.  She also performs skin/nerve/muscle biopsies and interprets biopsies.
     
    Dr. Zhou is a physician scientist.  Her research team is actively exploring the molecular mechanisms underlying muscle inflammation and fibrosis associated with muscular dystrophy and acute skeletal muscle injury repair.  Her research is aimed to develop novel pharmacotherapy to modify inflammation, reduce fibrosis, promote regeneration, and improve muscle function and phenotype in patients with muscular dystrophy.  Her research is funded by the National Institute of Health.

Research

Roles of chemokines and chemokine receptors in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is the most common, lethal, and currently untreatable genetic muscle disease.  Muscle pathology of DMD is featured by chronic inflammation and fibrosis, which directly lead to muscle dysfunction and clinical muscle weakness.  Ameliorating muscle inflammation and fibrosis may thus represent a viable therapeutic approach for DMD.  The chemokine system plays a key role in recruiting inflammatory cells and profibrogenic cells into injured muscles.  This research is to determine the roles of the chemokine system in inflammation and fibrosis associated with DMD and to explore the possibility of modifying inflammation, reducing fibrosis, and improving muscle function by altering the expression and function of related chemokines and chemokine receptors.  The DMD mouse models and relevant chemokine or chemokine receptor knockout mouse models are being used for the study.  

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Zhou did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Tel: 212-241-5949
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Tel: 212-241-6806
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Languages:
  • Chinese (Mandarin)
  • Chinese (Shanghai)
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