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John Oropello

  • PROFESSOR Surgery
  • PROFESSOR Medicine
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Certifications

  • Sleep Medicine

  • Critical Care Medicine

  • Pulmonary Disease

  • American Board of Internal Medicine

Education

  • MD, St. George's University

  • B.A., Bernard Baruch College
    Biology

  • M.D., St. George's University School of Medicine

  • Coney Island Hospital
    Internal Medicine, Department of Medicine

  • Coney Island Hospital
    Pulmonary, Department of Medicine

  • The Mount Sinai Hospital
    Critical Care, Department of Surgery

  • Residency, Internal Medicine
    Coney Island Hospital

  • Fellowship, Pulmonary
    Coney Island Hospital

  • Fellowship, Critical Care Med.
    Mount Sinai Hospital

Awards

  • 1990 -
    Fellow-of-the-Year Award Critical Care Fellowship
    The Mount Sinai Medical Center

  • 1989 -
    Consistent outstanding clinical performance during Internal Medicine Residency and Pulmonary Fellowship
    Coney Island Hospital

  • 1984 -
    The Abdool Islami Award for Overall Academic Excellence
    St. Georges' University, Grenada

  • 1978 -
    The President's Excellency Award for the
    Baruch College Honors Program, New York

  • 1978 -
    The Muriel Lee Winokur Biology Scholarship

  • 1978 -
    Magna Cum Laude with Honors in Biology
    Bernard Baruch College, New York, NY

Research

Research Projects Current:
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  • Kohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. A double blind, placebo-controlled, study of E5564, a lipid A antagonist, administered by twice daily intravenous infusions in patients with severe sepsis. \r\n\r\n
  • Benjamin E, Kohli-Seth R, Oropello JM, Leibowitz A, Manasia A, DelGiudice R, Hufanda J. Efficacy and safety of Drotrecogin (Alfa) in adult patients with early severe sepsis \r\n\r\n
  • Oropello JM, Kohli-Seth R, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Central venous access techniques: successful cannulation of central veins upon withdrawal of needle vs. advancement. \r\n\r\n
  • Kohli-Seth R, Oropello JM, Benjamin E, Manasia A, Leibowitz A, DelGiudice R, Hufanda J. Resting energy expenditure in morbidly obese septic and non-septic patients \r\n\r\n
  • Oropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. A Phase 2 study to determine the efficacy of Sivelestat in patients with Acute Lung Injury \r\n\r\n
  • Benjamin E Kohli-Seth R, Oropello JM Manasia A, Hannon E, DelGiudice R, Hufanda J Benign postoperative hyperlactatemia in Neurosurgical Patients \r\n\r\n
  • Benjamin E, Oropello JM, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Beginning and Ending Supportive therapy (BEST) for the Kidney Study \r\n
  • Oropello JM, Benjamin E, Manasia A, Kohli-Seth R, DelGiudice R, Hufanda J. Phase 3 multicenter randomized placebo study of PHP in sepsis with Shock. \r\n\r\n
  • A Manasia, Benjamin E, Oropello JM, R. Kohli-Seth, R DelGiudice, J Hufanda. Limited transthoracic echocardiography (TTE) by non-cardiologist surgical intensivists. \r\n\r\n
  • Oropello JM, Benjamin E, Manasia A, R. Kohli-Seth, R DelGiudice, J Hufanda.. J4A-MC-EZZI. A phase 2b Study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n\r\n
  • S. Chhabra, Benjamin E, Oropello JM, Manasia A, Victor Murgolo, R DelGiudice, J Hufanda. Zeroing of hydraulic monitoring systems using laser guidance. \r\n\r\n
  • Benjamin E, Oropello JM, Manasia A, Altschuller-Felberg C, Hufanda J, DelGiudice R: Multicenter, Double Blind, Placebo Controlled, Randomized, Phase III Study of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor [rTFPA/SC-59735]) in Severe Sepsis. \r\n\r\n
  • Benjamin E Oropello JM. Nierman D, Loren S, Hufanda J, DelGiudice R. Prospective study of anemia of critical illness and transfusion is critically ill patients. \r\n\r\n
  • Leibowitz A, Benjamin E, Oropello JM, Manasia, A, DelGiudice R., A randomized, open-labeled, pilot assessment of the effect of Protonix IV for injection (Pantoprazole Sodium) on gastric pH in ICU patients. \r\n\r\n
  • Oropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R, Hufanda J. . Open-label, comparative, randomized multicenter Phase 111 study of iv Synercid vs.Vancomycin or Nafcillin in the treatment of 380 patients with central venous catheter-related bacteremia. \r\n\r\n
  • Manasia A, Oropello JM, Benjamin E, Altschuller-Felberg C, DelGiudice R A Phase II, Dose-Ranging Evaluation of Safety and Efficacy of a-hANP for ARDS. \r\n\r\n
  • Kohli-Seth, Benjamin E. Oropello JM, Manasia, DelGiudice R, Hufanda J Amede F. The effect of continuous veno-venous hemofiltration (CVVH) on lung water as measured by transthoracic impedance analysis (TBIA). \r\n\r\n
  • Oropello JM, Altschuller-Felberg C, Benjamin E, Manasia A, DelGuidice R: rSP-c surfactant for the treatment of acute respiratory distress syndrome (ARDS), a randomized, multicenter, parallel group, controlled pilot study. \r\n\r\n
  • Oropello JM, Manasia A, Benjamin E, Altschuller-Felberg C, DelGuidice R: A phase II study to determine the efficacy and safety of LY315920 in patients with severe sepsis. \r\n \r\n
  • Benjamin E, Oropello JM, Manasia A, Altschuller-Felberg C Hufanda, J: Multicenter, single blind, placebo-controlled, randomized, dose escalation study of recombinant tissue factor pathway inhibitor (rTFOI/SC-59735) in severe sepsis. \r\n
  • Publications

    Oropello JM, Weiner L, Benjamin E. Hypertensive, hypervolemic, hemodilutional therapy for aneurysmal subarachnoid hemorrhage: Is it efficacious?--No. Crit Care Clin 1996; 12: 709-730.

    Manasia A, Kang H, Hannon E, Lu Y, Oropello JM, Leibowitz A, Stein J, Benjamin E. : Effects of the stable prostacyclin analogue iloprost on mesenteric blood flow in porcine endotoxic shock. Crit Care Med 1997; 25: 1222-1227.

    Benjamin E, Griffin K, Leibowtiz A, Manasia A, Oropello JM, Geffroy V, DelGuidice R, Hufanda J, Rosen S, Goldman M. Goal-Directed Transesophageal Echocardiography performed by intensivists to assess left ventricular function: comparison with pulmonary artery catheterization. J Cardiothorac Vasc Anesth 1998; 12: 10-15.

    Oropello JM, Leibowitz A, Geffroy V, Murgolo V, Ezeugwu C, Benjamin E. Hemodynamic waveform detection from pulmonary artery catheters in the ICU. Journal Intensive Care Med 1999 January; 14(1): 46-51.

    Naik S, Oropello JM, Benjamin E. Neurological complications of intensive care. Clinics In Chest Medicine 1999 June; 20(2): 423-434.

    Liolios A, Oropello JM, Benjamin E. Gastrointestinal complications of intensive care. Clinics in Chest Medicine 1999 June; 20(2): 329-345.

    Spencer KT, Goldman M, Cholley B, Hultman J, Benjamin E, Oropello JM, Harris KM, Bednarz J, Manasia A, Leibowitz A, Connor B, Lang RM. Multicenter experience using a new prototype transnasal transesophageal echocardiography probe. Echocardiography 1999; 16(8): 811-817.

    Kohli-Seth R, Oropello JM. The future of bedside monitoring. Crit Care Clin 2000 Oct; 16(4): 557-578.

    Barlas I, Oropello JM, Benjamin E. Neurological complications in the intensive care unit. Current Opinion in Critical Care 2001; 7: 68-73.

    Kang H, Manasia A, Rajamani S, Rajaram SS, Hannon E, Lu Y, Oropello JM, Benjamin E. Intravenous Iloprost increases mesenteric blood flow in experimental acute nonocclusive mesenteric ischemia. Crit Care Med 2002 Nov; 30(11): 2528-2534.

    Industry Relationships

    Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

    Below are financial relationships with industry reported by Dr. Oropello during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

    Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.

    • Instrumentation Laboratory

    Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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