BA, Columbia College
MPhil, Cambridge University
MD, PhD, Mount Sinai School of Medicine
MD, Mount Sinai Sch. of Medicine CUNY
Mount Sinai Hospital
Fellowship, Human Genetics
Mount Sinai Hospital
English, Italian, Spanish
Biophysics and Systems Pharmacology [BSP], Cancer Biology [CAB], Genetics and Genomic Sciences [GGS]
Mosig RA, Martignetti JA, DiFeo A, Ramirez MM, Parker IC, Abe E, Diouri J, Al Aqeel A, Wylie J, Oblander SA, Madri J, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Dowling O. Loss of MMP-2 disrupts early skeletal and craniofacial development, and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Human Molecular Genetics 2007;.
Camacho-Vanegas O, Narla G, Teixeira MS, Martignetti JA, Misra A, Friedman SL, Feuerstein BG, DiFeo A. Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma. Int. J of Onc 2007;.
Teixeira MS, Camacho-Vanegas O, Fernandez Y, Narla G, DiFeo A, Lee B, Martignetti JA, Friedman SL, Schlecht NF, Genden EM, Urken M, Brandwein-Gensler M, Kalir T. KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma. Int. J of Onc 2007;.
DiFeo A, Narla G, Hirshfeld J, Camacho-Vanegas O, Narla J, Rose SL, Martignetti JA, Yao S, Levine A, Birrer MJ, Bonome T, Friedman SL, Buller RE, Kalir T. Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination. Clin Cancer Res 2006; 12: 3730-3739.
DiFeo A, Narla G, Camacho-Vanegas O, Nishio H, Martignetti JA, Buller RE, Friedman SL, Walsh MJ, Rose SL. E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor. Oncogene 2006; 25: 6026-6031.
Narla G, DiFeo A, Yao S, Banno A, Hod E, Reeves HL, Martignetti JA, Camacho-Vanegas O, Levine A, Kirschenbaum A, Chan AM, Friedman SL, Qiao RF. Targeted inhibition of the KLF6 splice variant KLF6 SV1 suppresses prostate cancer cell growth and spread. Cancer Res 2005; 65: 5761-5768.
Narla G, Martignetti JA, Reeves HL, Schaid DJ, Hirshfeld J, Hod E, Katz A, Isaacs WB, Hebbring S, Komiya A, McDonnell SK, Wiley KE, Jacobsen SJ, Isaacs SD, Walsh PC, Zheng SL, Chang BL, Friedrichsen DM, Stanford JL, Ostrander EA, Chinnaiyan AM, Rubin MA, Xu J, Thibodeau SN, Friedman SL, Difeo A. A germline DNA polymorphism associated with increased prostate cancer risk enhances alternative splicing of the KLF6 tumor suppressor gene. Cancer Res 2005; 65: 1213-1222.
Dowling O, Martignetti JA, Ramirez MC, Tukel T, Narla G, Bonafe L, Kayserili H, Yuksel-Apak M, Paller AS, Norton K, Teebi AS, Grum-Tokars V, Martin GS, Davis GE, Glucksman MJ, Difeo A. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet 2003; 73: 957-966.
Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Friedman SL, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Glucksman MJ. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. Science 2001; 294: 2563-2566.
Martignetti JA, Al Aqeel A, Al Sewairi W, Boumah CE, Kambouris M, Al Mayouf S, Desnick RJ, Al Eid W, Dowling O, Harris J, Glucksman MJ, Bahabri S, Meyer BF, Sheth KV. Mutations in a human matrix metalloproteinase gene cause a multicentric osteolysis and arthritis syndrome. Nat Genet 2001; 28: 261-265.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Martignetti during 2015 and/or 2016. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Other activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.
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