- ASSISTANT PROFESSOR Psychiatry
- ASSISTANT PROFESSOR Neuroscience
Ph.D., New York University
- Through independent research and collaborations, Dr. Fan has conducted a series of studies on attentional networks. An Attention Network Test (ANT) was developed to provide a behavioral measure of the efficiency of the three attentional networks. Behavioral, developmental, patient, functional magnetic resonance imaging (fMRI), event related potentials (ERP), and genetics studies were conducted to investigate the anatomy, circuitry, pathology, and development of attentional networks. It was shown that the executive control network is highly heritable. Performance in resolving conflict relates to two dopamine genes. Subsequent imaging-genetic studies on a smaller genetically defined cohort showed that specific variants of the MAOA and DRD4 genes contribute to individual differences in functional activation of the anterior cingulate gyrus and other brain areas. The computational modeling offered the real possibility of linking and cross-validating findings from different studies and provided comprehensive predictions for the interactions among these networks.
Research in my laboratory is focused on understanding the mechanisms of neural circuits in human brain underlying cognitive functions, such as, attention, emotion, and memory, in normal and patient populations. We use multi-modal neuroimaging of event related functional magnetic resonance imaging (fMRI) for functional activity, structural MRI (mMRI) for morphometric differences, diffusion tensor imaging (DTI) for connectivity among brain areas, and magnetic resonance spectroscopy (MRS) for quantifying of endogenous neurochemistry. We are also involved in development of cognitive paradigms, new imaging acquisition, and analysis methods.
Current Students: Xiaosi Gu, Kevin G. Guise
Summary of Research Studies:
Research in my laboratory is focused on understanding the mechanisms of neural circuits in human brain underlying cognitive functions in normal and patient populations, with a focus on voluntary control. We use multi-modal neuroimaging of event related functional magnetic resonance imaging (fMRI) for functional activity, structural MRI (mMRI) for morphometric differences, diffusion tensor imaging (DTI) for structural connectivity among brain areas, magnetic resonance spectroscopy (MRS) for quantifying of endogenous neurochemistry, and event related potentials (ERP) for the time course of information transmission between brain networks.
Fan J, Hof PR, Guise K, Fossella JA, Posner MI. The functional integration of the anterior cingulate cortex during conflict processing. Cerebral Cortex 2008; 18(4): 796-805.
Fan J, Byrne J, Worden MS, Guise KG, McCandliss BD, Fossella J, Posner MI. The relation of brain oscillations to attentional networks. J Neurosci 2007; 27(3): 6197-6206.
Fan J, Kolster R, Ghajar J, Suh M, Knight RT, Sarkar R. Response anticipation and response conflict: An event-related potential and functional magnetic resonance imaging study. J Neurosci 2007; 27(9): 2272-2282.
Fan J, Mccandliss BD, Fossella J, Flombaum JI, Posner MI. The activation of attentional networks. Neuroimage 2005 Jun; 26(2): 471-479.
Fan J, Flombaum JI, Mccandliss BD, Thomas KM, Posner MI. Cognitive and brain consequences of conflict. Neuroimage 2003 Jan; 18(1): 42-57.
Fan J, Fossella J, Sommer T, Wu Y, Posner MI. Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci U S A 2003 Jun 10; 100(12): 7406-7411.
Fan J, Mccandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci 2002 Apr 1; 14(3): 340-347.
Fan J, Wu Y, Fossella J, Posner MI. Assessing the heritability of attentional networks. BMC Neuroscience 2001; 2: 14.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Fan did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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