Jian Jing

Research

Interneuronal functions in complex behaviors

We study how neural systems generate complex behaviors. We use a model system, the marine mollusk, Aplysia californica. Because neural networks in Aplysia contain a relatively small number of elements, Aplysia is well suited for such studies. Currently, we seek to gain insights into the question how is the activity of neurons that control distinct motor structures coordinated to generate functional behaviors. Our work is unique in that the focus of most other investigators is on how coordination is achieved within a single motor structure.

Our previous work was focused on the generation of behaviors by a single motor structure. This work investigated issues of neural coding, behavioral selection (decision making), and neuromodulation. Importantly, this work also identified a number of interneurons and processes that are likely to play a major role in coordinating motor outputs of distinct peripheral structures. Specifically, because various forms of coordination are to a large extent implemented by interneurons, a major goal of our research is to study functions of interneurons. We study neural circuits in considerable detail, both in terms of component neurons, and synaptic connections between these neurons. Furthermore, we identify the neurotransmitters/neuromodulators in these neurons using a variety of techniques, and study the functions of these neurotransmitters.

Independent of how complex animals are, their behaviors need to be coordinated to be successful. Therefore, we expect that basic mechanisms and principles uncovered in our research will have important implications for understanding how motor coordination is achieved in higher animals.