Dr. James Murrough is a Board-certified psychiatrist and a research fellow in the Mount Sinai School of Medicine Mood and Anxiety Disorders Program within the Department of Psychiatry. Dr. Murrough conducts experimental therapeutics and clinical neuroscience research in major depression, among other mood and anxiety disorders. Current focuses of his research include investigations of ketamine in treatment-resistant depression and brain mechanisms of antidepressant response measured using functional neuroimaging.Key Words: depression, bipolar disorder, posttraumatic stress disorder, psychopharmacology, antidepressants, functional neuroimaging
Psychiatry, American Board of Psychiatry and Neurology
Ketamine Plus Lithium as a Novel Pharmacotherapeutic Strategy in Treatment Resistant Depression
The purpose of this study is to test the antidepressant effect of ketamine when given repeatedly over a period of 1 week, as well as the use of Lithium as a relapse-prevention strategy for patients with treatment-resistant depression (TRD) who respond to an initial series of keta...
An fMRI Study of Ketamine in Treatment-Resistant Depression
The purpose of this study is to investigate the antidepressant mechanism of action of ketamine in patients with treatment-resistant major depression (TRD) using functional magnetic resonance imaging (fMRI). Ketamine is a N-methyl-D-aspartate (NMDA) glutamate receptor antagonist t...
A Proof-Of-Concept Clinical Trial of a Novel KCNQ Potentiator in Major Depressive Disorder
The purpose of this study is to test the safety tolerability and efficacy of ezogabine as a new antidepressant treatment for individuals suffering from major depressive disorder. Ezogabine is a potassium (K+) KCNQ2-selective channel potentiator and is believed to improve mood in ...
Intranasal Administration of Neuropeptide Y in PTSD
The purpose of this study is to evaluate the antidepressant and anti-anxiety effect of intranasal administration of neuropeptide Y (NPY) for patients with post-traumatic stress disorder (PTSD). NPY is not approved for the treatment of PTSD and is considered experimental in this s...
A double-blind, randomized, placebo-controlled, parallel group, dose frequency study of ketamine in subjects with treatment-resistant depression
The primary objective of this study is to evaluate the efficacy of intravenous (IV) ketamine administered 2 or 3 times a week for 4 weeks for the treatment of treatment-resistant depression. The study involves 4 weeks of either active ketamine or placebo. After 2 weeks of non-res...
A Double-Blind, Placebo-Controlled, Multicenter Study of Sirukumab as Adjunctive Treatment to a MonoAminergic Antidepressant in Adults with Major Depressive Disorder
The purpose of this study is to evaluate the efficacy of sirukumab as an adjunctive treatment to antidepressant therapy (monoaminergic antidepressant). Sirukumab will be administered as a subcutaneous injection three times during the 12-week double blind treatment period.
Murrough JW, Mathew SJ. Overcoming antidepressant treatment resistance: focus on glutamate. Modern Trends in Pharmacopsychiatry; 27.
Murrough JW, Mathew SJ. Neurochemical Imaging in Anxiety Disorders. Neuropsychiatric Imaging;.
Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, Levine SM, Mathew SJ, Shungu DC. Increased Ventricular Cerebrospinal Fluid Lactate in Chronic Fatigue Syndrome. Part II: Comparison with Major Depressive Disorder by 1H MRS at 3.0 Tesla. NMR Biomedicine 2010; 23: 643-650.
Murrough JW, Henry S, Hu J, Gallezot JD, Planeta-Wilson B, Neumaier JF, Neumeister A. Reduced ventral striatal/ventral pallidal serotonin(1B) receptor binding potential in major depressive disorder. Psychopharmacology (Berl) 2010 May;.
aan het Rot M, Collins KA, Murrough JW, Perez A, Reich DL, Charney DS, Mathew SJ. Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression. Biol Psychiatry 2010; 67: 139-145.
Mathew SJ, Murrough JW, aan het Rot M, Collins KA, Garakani A, Reich DL, Charney DS. Riluzole for Relapse Prevention Following Intravenous Ketamine in Treatment-Resistant Depression: A Pilot Randomized, Placebo-Controlled Study. Int J Neuropsychopharm 2010; 13: 71-82.
New AS, Fan J, Murrough JW, Liu X, Liebman RE, Guise KG, Tang CY, Charney DS. An Functional Magnetic Resonance Imaging Study of Deliberate Emotion Regulation in Resilience and Posttraumatic Stress Disorder. Biol. Psychiatry 2009; 66: 656-664.
Price RB, Shungu DC, Mao X, Nestadt P, Kelly C, Collins KA, Murrough JW, Charney DS, Mathew SJ. Amino Acid Neurotransmitters in the Occipital and Anterior Cingulate Cortices: Relationship to Treatment-Resistance in Major Depressive Disorder. Biol Psychiatry 2009; 65: 792-800.
Epstein J, Pan H, Kocsis JH, Yang Y, Butler T, Chusid J, Hochberg H, Murrough J, Strohmayer E, Stern E, Silbersweig DA. Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects. Am J Psychiatry 2006; 163: 1784-1790.
Murrough JW, Boss-Williams KA, Emery MS, Bonsall RW, Weiss JM. Depletion of Brain Norepinephrine Does Not Reduce Spontaneous Ambulatory Activity of Rats in the Home Cage. Brain Res 2000; 883: 125-130.
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Below are financial relationships with industry reported by Dr. Murrough during 2015 and/or 2016. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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