For more information, please visit the Bieker Laboratory website.
PhD, Northwestern University
, Washington University School of Medicine
, Rockefeller University
Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB], Genetics and Genomic Sciences [GGS]
Faculty Council Award for Academic Excellence
2012 Keynote Speaker
FASEB Conference on the Biology and Pathobiology of Krüppel-like Factors, Snowmass Village, CO
Tohoku Medical Society Testimonial
Tohoku University, Sendai, Japan
Weatherall Institute of Molecular Medicine, Oxford University, Oxford UK
Scholar of the Leukemia Society of America
Leopold Marcus Award for Research in Chemistry
Bieker JJ. EKLF and the development of the erythroid lineage. In: Ravid K, Licht J, editors. Transcription Factors: Normal and Malignant Development of Blood Cells (2000).
Bieker JJ. Krüppel-like factors: three fingers in many pies. The Journal of biological chemistry 2001 Sep; 276(37): 34355-58.
Siatecka M, Xue L, Bieker JJ. Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Molecular and cellular biology 2007 Dec; 27(24): 8547-60.
Frontelo* P, Manwani* D, Galdass M, Karsunky H, Lohmann F, Gallagher PG, Bieker JJ. Novel role for EKLF in megakaryocyte lineage commitment [highlighted as an Inside Blood preview]. Blood 2007 Dec; 110(12): 3871-80 [*co-first authors].
Manwani D, Bieker JJ. The erythroblastic island. Current topics in developmental biology 2008; 82: 23-53.
Quadrini KJ, Gruzglin E, Bieker JJ. Non-random subcellular distribution of variant EKLF in erythroid cells. Experimental cell research 2008 Apr; 314(7): 1595-1604.
Lohmann F, Bieker JJ. Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment [highlighted as an In this Issue preview]. Development (Cambridge, England) 2008 Jun; 135(12): 2071-2082.
Sengupta T, Chen K, Milot E, Bieker JJ. Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Molecular and cellular biology 2008 Oct; 28(20): 6160-70.
Sengupta T, Cohet N, Morlé F, Bieker JJ. Distinct modes of gene regulation by a cell-specific transcriptional activator. Proceedings of the National Academy of Sciences of the United States of America 2009 Mar; 106(11): 4213-18.
Siatecka M, Lohmann F, Bao S, Bieker JJ. EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation. Molecular and cellular biology 2010 Jun; 30(11): 2811-22.
Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker* JJ, Peters* LL. Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor [highlighted in Hematopoiesis News; highlighted in Health and Medicine Week]. Proceedings of the National Academy of Sciences of the United States of America 2010 Aug; 107(34): 15151-56 [*co-corresponding authors] .
Bieker JJ. Putting a finger on the switch. Nature genetics 2010 Sep; 42(9): 733-734.
Chen J, Peterson KR, Iancu-Rubin C, Bieker JJ. Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo [highlighted in Sickle Cell News; highlighted in SciBX]. Proceedings of the National Academy of Sciences of the United States of America 2010 Sep; 107(39): 16846-51.
Siatecka M, Bieker JJ. The multifunctional role of EKLF/KLF1 during erythropoiesis. Blood 2011 Aug; 118(8): 2044-2054.
Yien YY, Bieker JJ. EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Molecular and cellular biology 2013 Jan; 33(1): 4-13.
Varricchio L, Dell'Aversana C, Nebbioso A, Migliaccio G, Altucci L, Mai A, Grazzini G, Bieker JJ, Migliaccio AR. Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells. The international journal of biochemistry & cell biology 2014 May; 50: 112-22.
Xue L, Galdass M, Gnanapragasam MN, Manwani D, Bieker JJ. Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche. Development (Cambridge, England) 2014 Jun; 141(11): 2245-54.
Soni S, Pchelintsev N, Adams PD, Bieker JJ. Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression [highlighted in Hematopoiesis News]. Proceedings of the National Academy of Sciences of the United States of America 2014 Sep; 111(37): 13337-42.
Yien* YY, Gnanapragasam* MN, Gupta R, Rivella S, Bieker JJ. Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues. Experimental hematology 2015 Jan; 43(1): 65-70 [*co-first authors].
Siatecka M, Soni S, Planutis A, Bieker JJ. Transcriptional Activity of Erythroid Kruppel-like Factor (EKLF/KLF1) Modulated by PIAS3 (Protein Inhibitor of Activated STAT3). The Journal of biological chemistry 2015 Apr; 290(15): 9929-40.
Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, Bigarella CL, Rimmelé P, Zhang X, Gnanapragasam MN, Bieker JJ, Papatsenko D, Ma'ayan A, Bresnick E, Fowler V, Palis J, Ghaffari S. A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS genetics 2015 Oct; 11(10).
Lohmann F, Dangeti M, Soni S, Chen X, Planutis A, Baron MH, Choi K, Bieker JJ. The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells. Molecular and cellular biology 2015 Nov; 35(21): 3726-38.
Aimola IA, Inuwa HM, Nok AJ, Mamman AI, Bieker JJ. Cis-vaccenic acid induces differentiation and up-regulates Gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor Stem Cells. European journal of pharmacology 2016 Feb;.
Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S. "Krüppeling" erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants unveiled by genomic sequencing. Blood 2016 Feb;.
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