- DEAN FOR TRANSLATIONAL BIOMEDICAL RESEARCH
- PROFESSOR Pediatrics, Allergy and Immunology
American Board of Allergy & Immunology
American Board of Pediatrics
MD, S.U.N.Y., Buffalo
Children's Memorial Hospital
Fellowship, Allergy & Immunology
Duke University Hospital
- Dr. Sampson is the Kurt Hirschhorn, M.D./Children’s Center Foundation Professor of Pediatrics and the Dean for Translational Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. He is the Director of the Jaffe Food Allergy Institute and the Director and PI of the NIH-sponsored CTSA program, Conduits – the Institutes for Translational Sciences at Icahn School of Medicine at Mount Sinai. Dr. Sampson's research interests have focused on food allergic disorders, and now include work on the pathogenesis of food-induced anaphylaxis, characterization of allergenic food proteins and their processing by the immune system, genetics of food allergy, development of novel diagnostic tests, and mechanisms of immunotherapeutic strategies for treating food allergies including basic studies and clinical trials in oral, sublingual and epicutaneous immunotherapy and the potential use of biologics, such as anti-IgE and anti-cytokine monoclonal antibodies. His research is funded by a number of grants from the National Institutes of Health and private foundations (Food Allergy Research and Education), and he is the PI on the NIH-sponsored Consortium of Food Allergy Research. Dr. Sampson supervises one clinic/week in pediatric allergy and is involved in teaching fellows and residents.
In the News
Dr. Sampson talks about food allergies in The DailyNews feature The Daily Check Up. View the PDF.
Dr. Sampson discusses childhood food allergies in The Daily News feature The Daily Check Up.
Brett Ratner Award
American Academy of Pediatrics
2003 - present
Outstanding Research in Food Hypersensitivity Disorders
Institute of Medicine; National Academy of Science
International Award in Nutrition
2001 - 2011
New York Top Doctors
NY Magazine's top clinical doctors in New York
1986 - 1991
Allergic Disease Academic Award
NIAID competitive award for research in food allergy
Specific Clinical/Research Interest: Immunopathogenic mechanisms of food allergic disorders and asthma; immunomodulatory therapies
Postdoctoral Fellows: Jacob Kattan, MD
Research Personnel: Alexander Grishin, PhD; Madhan Masilamani, PhD, Jing S Lin, PhD, Luda Bardina, MS; Galina Grishin, MS; Gustavo Gimenez, BS, Mohanapriya Kamalakannan, BS
Summary of Research Studies:
Our laboratory is evaluating immunopathologic mechanisms of food allergic disorders. Specifically we are identifying allergenic proteins at a molecular and structural level, and investigating the interaction between IgE antibodies and allergenic proteins and the immune response at a cellular and molecular level. Studies utilize patient specimens and murine models in an attempt to elucidate underlying mechanisms. Allergenic proteins in egg, milk, peanut, several tree nuts, shrimp and some fish have been fully characterized and full-length cDNAs isolated and cloned. A number of therapeutic strategies are under investigation utilizing murine models of anaphylaxis and asthma including the use of recombinant proteins, DNA vaccines, and CpG-conjugated proteins. Several early stage, human clincial trials are in progress to treat food allergic disorders including oral and sublingual immunotherapy, herbal therapies, and engineered recombinant protein vaccines.
In addition, our laboratory is serving as the mechanistic center for the NIAID Inner City Asthma Consortium and the Consortiium for Food Allergy Research. The asthma consortium is investigating the role of allergic sensitization in inner city children and its potential role in the increased morbidity and mortality found in this population. The overall goal is to determine whether the nature and quantity of environmental allergens within the inner city, especially cockroach, are unique in their ability to determine and drive the intensity of allergic inflammation in sensitized children residing in the inner city and thus the severity of their asthma.
The food allergy consortium is investigating the immunologic mechanisms associated with the devleopment of peanut allergy and the development of tolerance ["outgrowing"] to egg and milk allergy, the immunologic consequences of oral immunotherapy for egg allergy, and the immunologic consequences of sublingual immunotherapy for peanut allergy. The lab employs a variety of techniques to identify and purify proteins including SDS-PAGE, immunoblotting and HPLC. Recombinant proteins are generated from cDNA isolated from appropriate cDNA libraries. A variety of techniques are utilized to study both humoral and cellular responses of patient groups and controls. Characterization of cellular responses includes intracytoplasmic staining, mRNAgeneration, and characterization of cytokines secreted into cell supernatants. Similar studies are conducted in the murine models.
Jaffe Food Allergy Institute
Shreffler WG, Lencer DA, Bardina L, Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol 2005; 116: 893-899.
Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Cooke SH, Sampson HA. Specificity of IgE antibodies to linear epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007; 62: 758-765.
Beyer K, Grishina G, Bardina L, Sampson HA. Identification of two new sesame seed allergens -Ses i 6 and Ses i 7. J Allergy Clin Immunol 2007; 119: 1554-1556.
Chehade M, Sampson HA, Morotti RA, Magid MS. Esophageal subepithelial fibrosis in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2007 Sep; 45(3): 319-328.
Han N, Jarvinen KM, Cocco RR, Busse PJ, Sampson HA, Beyer K. Identification of amino acids critical for IgE-binding to sequential epitopes of bovine kappa-casein and the similarity of these epitopes to the corresponding human kappa-casein sequence. Allergy 2008 Feb; 63(2): 198-204.
Jarvinen KM, Han N, Cocco R, Busse PJ, Sampson HA, Beyer K. Identification of Amino Acids Critical for IgE-binding to Bovine-Casein and Potential homology between of IgE-binding Epitopes of Cow's Milk Caseins and Caseins of Man. Allergy 2008; 63(2): 198-204.
Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, Sampson HA. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 2008 Aug; 122(2): 342-347.
Cerecedo I, Zamora J, Shreffler WG, Lin J, Bardina L, Dieguez MC, Wang J, Muriel A, de la Hoz B, Sampson HA. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol 2008 Sep; 122(3): 589-594.
Lemon-Mule H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008 Nov; 122(5): 977-983.
Shreffler WG, Wanich N, Maloney M, Nowak-Wegrzyn A, Sampson HA. The Association of Allergen-Specific Regulatory T Cells with the Onset of Clinical Tolerance to Milk Protein. J Allergy Clin Immunol 2009 Jan; 123(1): 43-52.
Pochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K. Targeting Toll-like receptors on dendritic cells modifies the T(H)2 response to peanut allergens in vitro. The Journal of allergy and clinical immunology 2010 Jul; 126(1).
Konstantinou GN, Ramon B, Grishin A, Caubet JC, Bardina L, Sicherer SH, Sampson HA, Nowak-Wegrzyn A. The role of casein-specific IgA and TGF-beta in children with Food Protein-Induced Enterocolitis Syndrome to milk. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2014 Oct;.
Tordesillas L, Goswami R, Benede S, Grishina G, Dunkin D, Jarvinen KM, Maleki SJ, Sampson HA, Berin MC. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. The Journal of clinical investigation 2014 Oct;.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Sampson during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Allertein Therapeutics, LLC; MedImmune, LLC; Regeneron Pharmaceuticals
Scientific Advisory Board:
- DBV Technologies; Danone Research
Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.
- Herbal Springs LLC
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- Allertein Therapeutics, LLC; Herbal Springs LLC
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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