Axon Guidance, Axonal Growth and Degeneration, Brain, Cancer Genetics, Developmental Neurobiology, Epigenetics, Neurobiology, Regeneration, Spinal Cord, Stem Cells, Transcription Factors, Tumorigenesis
Genetics and Genomic Sciences [GGS], Neuroscience [NEU]
MD, Stanford University School of Medicine
PhD, Cornell University and Memorial Sloan-Kettering Institute
Internship, General Surgery
Stanford University Hospital
Stanford University Hospital
Chinese (Cantonese), Chinese (Mandarin), English
National Institutes of Health
Award for the research of brain tumor biology
National Innovative Research Award Grant
American Heart Association
Craig H. Neilsen Foundation Award
National Institutes of Health
Award for the research of molecular mechanisms to promote axon regeneration
Dr. Harold and Golden Lamport Research Award
The award is given to tenure-track assistant professors who show exceptional potential for making significant contributions.
Young Clinician Investigator Award for Young Faculty
NREF (Neurosurgery Research and Education Foundation) of the AANS (American Association of Neurological Surgeons)
Transcriptional regulation of the intrinsic axon growth capacity during development
Grant supporting research for basic neuroscience
Congress of Neurological Surgeons Resident Award
NRSA/NINDS Postdoctoral Fellowship
Baxter Foundation Grant
Julian R. Rachele Prize
Frank Lappin Horsfall Jr. Fellowship
Specific Research Interests:
-Molecular mechanisms of axonal growth;
-Transcription factors regulating axonal regeneration;
-Neural stem cell proliferation, differentiation and implication in CNS tumorigenesis.
Our lab is interested in understanding how neurons are born, how they extend axons, and how they regenerate or fail to regenerate after injury. Brain and spinal cord injuries account for billions of dollars each year in medical costs. Understanding classic and identifying novel signaling pathways that promote neurogenesis and axonogenesis will provide new molecular targets towards effective CNS regeneration. Similar mechanisms that regulate the neural stem cell (NSC) niche also regulate tumor stem cells (TSCs). Developing strategies to shrink the TSC pool by inhibiting proliferation, inducing apoptosis or promoting differentiation will have great impact on treating primary brain tumor, which is one of the leading causes of death in children and young adults.
Zou H, Niswander L. Requirement for BMP signaling in interdigital apoptosis and scale formation. Science 1996 May 3; 272: 738-741.
Zou H, Choe KM, Lu Y, Massague J, Niswander L. BMP signaling and vertebrate limb development. Cold Spring Harbor Symposia on Quantitative Biology 1997; 62: 269-272.
Zou H, Wieser R, Massague J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes & Development 1997 Sep 1; 11(17): 2191-2203.
Varley JE, McPherson CE, Zou H, Niswander L, Maxwell GD. Expression of a constitutively active type I BMP receptor using a retroviral vector promotes the development of adrenergic cells in neural crest cultures. Developmental Biology 1998 Apr 1; 196(1): 107-118.
Zou H, Lu QC, Durack JC, Chao C, Strasberg HR, Zhang Y, Tsai M, Melmon K, Hahn JS. Structured data management--the design and implementation of a web-based video archive prototype. Proceedings / AMIA ... Annual Symposium. AMIA Symposium 2001;.
Zou H, Ho C, Wong K, Tessier-Lavigne M. Axotomy-induced Smad1 Activation Promotes Axonal Growth in Adult Sensory Neurons. The Journal of Neuroscience 2009; 29(22): 7116-7123.
Parikh P, Hao Y, Hosseinkhani M, Patil SB, Huntley GW, Tessier-Lavigne M, Zou H. Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons. PNAS 2011 Apr;.
Pricola KL, Zou H, Chang SD. Successful repair of a gunshot wound to the head with retained bullet in the torcular herophili. World Neurosurgery; 76(3-4).
Mascitelli J, De Los Reyes K, Steinberger J, Zou H. Lack of functionality and need for revision of an Ommaya reservoir placed into a cavum septum pellucidum. Journal of Neurosurgery 2013 Mar; 118(3).
Finelli MJ, Murphy KJ, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Reports 2013 May; 3(5).
Finelli MJ, Wong JK, Zou H. Epigenetic regulation of sensory axon regeneration after spinal cord injury. The Journal of neuroscience 2013 Dec; 33(50).
O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J. B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. The Journal of Experimental Medicine 2014 May; 211(5).
Zhong J, Zou H. BMP signaling in axon regeneration. Current Opinion in Neurobiology 2014 Aug; 27.
Wong JK, Zou H. Reshaping the chromatin landscape after spinal cord injury. Frontiers in Biology 2014 Oct; 9(5).
Wong JK, Chen L, Huang Y, Sehba FA, Friedel RH, Zou H. Attenuation of Cerebral Ischemic Injury in Smad1 Deficient Mice. PloS One 2015; 10(8).
Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH. Double minute amplification of mutant PDGF receptor α in a mouse glioma model. Nature Scientific Reports 2015; 5.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH. Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget 2015 Mar; 6(9).
Daviaud N, Chen K, Huang Y, Friedel RH, Zou H. Impaired cortical neurogenesis in Plexin-B1 and -B2 double deletion mutant. Developmental Neurobiology 2015 Nov;.
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Dr.Zou did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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