- PROFESSOR | Psychiatry
- Hospital Affiliation
- The Mount Sinai Hospital
Dr. Koenigsberg’s primary area of interest is in the integration of psychological experience with underlying neural processes. A principal focus of his interest is the inter-relationship between neurobiologic, psychological and social contributors to personality and its disorders. Dr. Koenigsberg has been awarded 17 years of continuous funding as principal investigator of R01 research grants funded by the National Institute of Mental Health. Dr. Koenigsberg’s current work focuses on mood regulation, social cognitive neuroscience and in the psychobiology and treatment of borderline and schizotypal personality disorders. He is currently conducting several fMRI studies which image the brain’s activity during emotional processing and during memory retention processes in healthy volunteers and in patients with borderline personality disorder, avoidant personality disorder, schizotypal personality disorder, schizophrenia, and trans-diagnostically across the affective instability spectrum. He is also studying the role of second messenger systems in emotional instability in the personality disorders.
Dr. Koenigsberg is a Distinguished Life Fellow of the American Psychiatric Association and a Fellow of the American College of Neuropsychopharmacology. He is an emeritus member of the American College of Psychiatrists. He served as an advisor to the Personality Disorders task forces of both the DSM-IV and DSM-5 American Psychiatric Association diagnostic classification systems. He is a member of the editorial board of the Journal of Personality Disorders and has served on the Scientific Program Committee of the Society for Biological Psychiatry. Dr. Koenigsberg is a member of the board of directors of the International Society for the Study of Personality Disorders. He co-chaired the 11th International Congress of the International Society for the Study of Personality Disorders. In addition to his medical degree, Dr. Koenigsberg holds an MA in Physics from Columbia University.
Financial & Billing Information
Please direct any detailed billing or financial inquires to the Mount Sinai Psychiatry billing customer service number at 212-659-8752.
Psychiatry, American Board of Psychiatry and Neurology
Brain Imaging, Imaging, Neuroscience
Multi-Disciplinary Training Areas
Clinical Research Education Program [CLR], Neuroscience [NEU]
MD, Albert Einstein College of Medicine
Bronx Municipal Hospital Center
Fellowship, Inpatient Psych
New York Hospital
Biological Correlates of Personality Disorder
Results of recent research studies suggest that genetic and biologic factors may greatly influence the development of personality. In order to help patients who have severe disturbances of personality, doctors need to know more about these factors. These studies are intended to e...
An fMRI Study of the Enhancement of Emotion Regulation in Borderline Patients
This study explores what causes borderline patients to have emotional lability. One possible cause is that they are unable to employ thinking strategies to emotionally distance themselves from distressing stimuli in the way that healthy controls successfully do. BPD patients may ...
A Pilot fMRI Study to Investigate the Impact of Oxytocin Administration on the Behavioral and Neural Mechanisms of Interpersonal Cooperation in Borderline Personality Disorder and Healthy Adults
The neuropeptide oxytocin has been shown to increase trust, reduce reactivity to emotional stimuli in the amygdala—a limbic brain region associated with negative emotional response— and selectively increase empathy and empathic accuracy in healthy adults. Since impairment in trus...
Koenigsberg HW, Fan J, Ochsner KN, Liu X, Guise KG, Pizzarello S, Dorantes C, Guerreri S, Tecuta L, Goodman M, New A, Siever LJ. Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder. Biological psychiatry 2009 Nov; 66(9).
Koenigsberg HW, Siever LJ, Lee H, Pizzarello S, New AS, Goodman M, Cheng H, Flory J, Prohovnik I. Neural correlates of emotion processing in borderline personality disorder. Psychiatry research 2009 Jun; 172(3).
Koenigsberg HW. Affective instability: toward an integration of neuroscience and psychological perspectives. Journal of personality disorders 2010 Feb; 24(1).
Koenigsberg HW, Siever LJ. Borderline personality disorder . In: New encyclopedia of neuroscience, Squire L, Albright T, Bloom F,Gage F, & Spitzer N (Eds). Elsevier;.
Koenigsberg HW, Woo-Ming AM, Siever LJ, Nathan PR, Gorman JM (Eds). Psychopharmacological treatment of personality disorders. In: A guide to treatments that work, 3rd edition. New York: 2007, Oxford University Press;.
Koenigsberg HW, Harvey PD, Mitropoulou V, Schmeidler J, New AS, Goodman M, Silverman J, Serby M, Schopick F, Siever LJ. Characterizing affective instability in borderline personality disorder. Am J Psychiatry 2002; 159: 784-88.
Koenigsberg HW, Kernberg OF, Stone MH, Appelbaum AH, Yeomans FE, Diamond D. Borderline patients: extending the limits of treatability. New York: 2000, Basic Books; 2000.
Koenigsberg HW, Buchsbaum MS, Buchsbaum BR, Schneiderman JS, Tang CY, New A, Goodman M, Siever LJ. Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis. Psychol Med 2005 Jul; 35(7): 1019-1030.
Koenigsberg HW, Reynolds D, Goodman M, New AS, Mitropoulou V, Trestman R, Silverman J, Siever LJ. Risperidone in the treatment of schizotypal personality disorder. J Clin Psychiatry 2003; 64: 628-34.
Koenigsberg HW, Teicher MH, Mitropoulou V, Navalta C, New AS, Trestman R, Seiver LJ. 24-Hour monitoring of plasma norepinephrine, MHPG, cortisol, growth. J Psychiatr Res 2004; 38: 503-11.
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Dr.Koenigsberg did not report having any of the following types of financial relationships with industry during 2016 and/or 2017: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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