- RESEARCH PROFESSOR | Psychiatry
- RESEARCH PROFESSOR (PENDING) | Neurology
Aging, Alzheimer's Disease, Brain, Endothelial Cells, Neuro-degeneration/protection, Stem Cells
Multi-Disciplinary Training Area
BA, University of Illinois
Research interests include Alzheimer's disease and related dementias, in particular how mutations in presenilin-1 cause familial Alzheimer's disease using transgenic mouse models. We also study the normal biological functions of the presenilin-1 gene using mouse models and cell culture.
Familial Alzheimer's disease
De Gasperi R, Gama Sosa MA, Wen PH, Li J, Curran T, Elder GA. Cortical Development in the Presenilin-1 Null Mutant Mouse Fails After Splitting of the Preplate and is Not Due to a Failure of Reelin-Dependent Signaling. Developmental Dynamics 2008; 237: 2405-2414.
De Gasperi R, Rocher AB, Gama Sosa MA, Wearne SL, Perez GM, Friedrich VL Jr, Hof PR, Elder GA. The IRG Mouse: A Two-Color Fluorescent Reporter for Assessing Cre-Mediated Recombination and Imaging Complex Cellular Relationships In Situ. Genesis 2008; 46: 308-317.
Elder GA, Ragnauth A, Dorr N, Franciosi S, Schmeidler J, Haroutunian V, Buxbaum JD. Increased locomotor activity in mice lacking the low-density lipoprotein receptor. Behavioral Brain Research 2008; 191: 256-265.
Gama Sosa MA, De Gasperi R, Rocher AB, Perez GM, Simons K, Cruz DE, Hof PR, Elder GA. Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact. Cell Research 2007; 17: 619-626.
Elder GA, Cho J, English DF, Franciosi S, Schmeidler J, Gama Sosa MA, De Gasperi R, Fisher EA, Mathews PM, Haroutunian V, Buxbaum JD, . Elevated plasma cholesterol does not affect brain in mice lacking the low-density lipoprotein receptor. Journal of Neurochemistry 2007; 102: 1220-1231.
Franciosi S, De Gasperi R, Dickstein DL, English DF, Rocher AB, Janssen WM, Christoffel D, Gama Sosa MA, Hof PR, Buxbaum JD, Elder GA. Pepsin Pretreatment Allows Collagen IV Immunostaining of Blood Vessels in Adult Mouse Brain. Journal of Neuroscience Methods 2007; 163: 76-82.
Elder GA, De Gasperi R, Gama Sosa MA. Research Update: Neurogenesis in Adult Brain and Neuropsychiatric Disorders. The Mount Sinai Journal of Medicine 2006; 73: 931-940.
Wen PH, De Gasperi R, Gama Sosa MA, Rocher AB, Friedrich Jr. VL, Hof PR, Elder GA. Selective expression of presenilin-1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin-1 null mutant mice. Development 2005; 132: 3873-3883.
Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Experimental Neurology 2004; 188: 224-237.
Gama Sosa MA, Wen PH, De Gasperi R, Perez G, Senturk E, Friedrich Jr. VL, Elder GA. Entorhinal Cortex Lesioning Promotes Neurogenesis in the Hippocampus of Adult Mice. Neuroscience 2004; 127: 881-891.
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Dr.Elder did not report having any of the following types of financial relationships with industry during 2017 and/or 2018: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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