- ASSOCIATE PROFESSOR Pharmacology and Systems Therapeutics
Dr. Harold and Golden Lamport Research Award
Mount Sinai School of Medicine
Specific Research Interest:
Mechanisms underlying cardiac dysfunction and arrhythmias using physiological experiments coupled with mathematical modeling
Postdoctoral Fellows: Young-Seon Lee, Eva Polakova
Graduate and Medical Students: John Jones Molina, Megan Cummins, Ryan Devenyi, Pavan Dalal
Undergraduates and Visitors: Kathleen McGovern, Alessandro Giovannini, Allie Lopatkin
Research Personnel: Frank Fabris
The Sobie Laboratory combines mathematical modeling with state-of-the-art experimental techniques in order to improve our quantitative understanding of cardiac physiology. We generate predictions using mathematical models, then test these predictions experimentally by measuring calcium and transmembrane voltage in heart cells. This provides novel insight into the initiation of arrhythmias and dysfunction that occurs in disease states such as heart failure. Specific research projects are described in more detail at our lab website.
Keywords: Biophysics, Calcium, Computer Simulation, Electrophysiology, Heart, Mathematical and Computational Biology, Systems Biology
Current Research Studies:
2010-2013: Novel computational approaches for understanding drug-induced arrhythmia. American Heart Association 10GRNT4170020. The goal of this project is to use new computational methods to understand sources of inter-patient variability in arrhythmias caused by pharmacological agents.
2005-2014: Sarcoplasmic reticulum calcium leak and calcium instability in cardiac myocytes; National Institutes of Health R01 HL 076230; The goal of this project is to investigate, through experiments and simulation, sources of unstable, potentially arrhythmogenic calcium release in cardiac myocytes.
2007-2012: Systems Biology Center in New York. National Institutes of Health P50 GM071558-01; Dr. Sobie leads one of the projects in this multi-investigator grant. We are developing methods for explicit multi-scale simulations of heart function.
Sarkar AX, Christini DJ, Sobie EA. Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol 2012;.
Liu OZ, Lederer WJ, Sobie EA. Does the Goldilocks Principle apply to calcium release restitution in heart cells?. J Mol Cell Cardiol 2012; 52: 3-6.
Sobie EA, Lederer WJ. Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles. J Mol Cell Cardiol 2012; 52.
Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman GI, Sobie EA, Coetzee WA. Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system. Circulation. Arrhythmia and Electrophysiology 2011; 4.
Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS. Dynamics of calcium sparks and calcium leak in the heart. Biophys J 2011; 101.
Sarkar AX, Sobie EA. Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm 2011 Nov; 8(11).
Ramay HR, Liu OZ, Sobie EA. Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity. Cardiovasc Res 2011; 91.
Sobie EA, Lee YS, Jenkins SL, Iyengar R. Systems biology--biomedical modeling. Science Signaling 2011; 4.
Lee YS, Dun W, Boyden PA, Sobie EA. Complex and rate-dependent beat-to-beat variations in Ca²⁺ transients of canine Purkinje cells. J Mol Cell Cardiol 2011; 50.
Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B, Entcheva E. Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB Journal 2011; 25.
Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol 2011; 51.
Sarkar AX, Sobie EA. Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. PLoS Comput Biol 2010; 6: e1000914.
Hartman JM, Sobie EA, Smith GD. Spontaneous calcium sparks and calcium homeostasis in a minimal model of permeabilized ventricular myocytes. Am J Physiol Heart Circ Physiol 2010; 299: H1996-2008.
Remay HR, Jafri MS, Lederer WJ, Sobie EA. Predicting local SR Ca²⁺ dynamics during Ca²⁺ wave propagation in ventricular myocytes. Biophys J 2010; 98: 2515-2523.
MacQuaide N, Ramay HR, Sobie EA, Smith GL. Differential sensitivity of Ca²⁺ wave and Ca²⁺ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. J Physiol 2010; 588.
Sobie EA. Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J 2009; 96: 1264-1274.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Sobie during 2014 and/or 2015. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Gilead Sciences, Inc.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
Icahn Medical Institute Floor 12 Room 12-52 (Lab)
1425 Madison Avenue
New York, NY 10029
Icahn Medical Institute Floor 12 Room 12-70F (Office)
1425 Madison Avenue
New York, NY 10029