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Effie M. Mitsis

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  • Yale University School of Medicine

  • Yale University School of Medicine

  • Ph.D., The Graduate Center of the City University of New York
    Neuropsychology Doctoral Subprogram


    Effie Mitsis, Ph.D. is an Associate Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai in New York City. She is affiliated with the James J. Peters VA Medical Center within the Department of Neurology as a neuropsychologist and is the past Vice Chair of the Institutional Review Board. Dr. Mitsis received her doctorate in neuroscience and neuropsychology at the Graduate School and University Center of the City University of New York and conducted her dissertation research at Columbia University College of Physicians and Surgeons. Dr. Mitsis completed one-year pre-doctoral and three-year postdoctoral fellowships in neuroimaging and neuropsychology at Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, West Haven campus. Dr. Mitsis is a past board member of the Medical and Scientific Advisory Council for the Connecticut chapter of the Alzheimer’s Association.  

    At Mount Sinai, Dr. Mitsis conducts neuroimaging research in traumatic brain injury (TBI), aging and dementia within the renowned Alzheimer’s Disease Research Center. She is currently funded with an intramural grant to use PET and magnetic resonance imaging to investigate history of traumatic brain injury as a risk factor for earlier onset of Alzheimer’s disease in individuals with Mild Cognitive Impairment, typically referred to as MCI. MCI is considered the very early or prodromal stage of Alzheimer’s disease. She is funded also with an intramural grant to use [18F] florbetapir imaging (Amyvid®) to determine whether individuals with and without a history of TBI are at risk for Alzheimer’s disease or chronic traumatic encephalopathy (CTE), typically associated with multiple concussions as seen in former boxers and professional football players.

    Dr. Mitsis’s current area of focus, for which she is extramurally funded through the Veterans Affairs administration as Principal Investigator, is mild traumatic brain injury associated with blast exposure in combat veterans returning from theaters of war in Iraq and Afghanistan. Dr. Mitsis is actively investigating the cognitive and neurobiological consequences of blast-exposure TBI in these veterans, and is initiating studies to investigate the association between prior head injury, genetics, and earlier onset of dementia. Her findings have been published in numerous peer-reviewed journals and she has written chapters addressing research advances in neuroimaging in Alzheimer’s disease and Mild Cognitive Impairment. She is a frequent invited speaker at forums addressing Alzheimer’s disease, MCI, and TBI, and is a member of several national and international organizations for the imaging sciences and neuropsychology.


Mitsis EM, van Dyck CH. Neuroimaging in Alzheimer's Disease and Mild Cognitive Impairment. In: Research Progress in Alzheimer's Disease and Dementia
Neuroimaging in Alzheimer's Disease and Mild Cognitive Impairment. New York, Nova Science Publishers;.

Mitsis EM, Cosgrove KP, Staley JK, Frohlich E, van Dyck CH, Tamagnan GD, Estok KM, Seibyl JP, Bois F. Age-related decline in nicotinic receptor availability using [123I]5-IA-85380 SPECT. Neurobiology of Aging 2007;.

Mitsis EM, Bobinsky M, Brys M, Glodzik-Sobanska L, DeSanti S, Li Y, Kim B, De Leon MJ. Neuropathological and neuroimaging studies of the hippocampus in normal aging and in Alzheimer’s disease. In: Charney DS, Nestler EJ, editors. Neurobiology of Mental Illness, 3rd Edition. New York, Oxford University Press;.

Mitsis EM, Estok KM, Staley JK, Bois F, Santosh L, MacAvoy MG, Seibyl JP, van Dyck CH. [123I]5-IA-85380 SPECT imaging of 2-nicotinic receptors in Alzheimer’s disease and mild cognitive impairment. Journal of Nuclear Medicine 2009; 50: 1455-1463.

Zhang J, Mitsis EM, Chu K, Newmark RE, Hazlett EA, Buchsbaum MS. Statistical parametric mapping and cluster counting analysis of [18F] FDG-PET imaging in traumatic brain injury. Journal of neurotrauma 2010 Jan; 27(1).

Mitsis EM, Jacobs D, Lou X, Andrews H, Andrews K, Sano M. Evaluating cognition in the elderly via telephone assessment. International Journal of Geriatric Psychiatry 2010; 25: 531-539.

Elder GA, Mitsis EM, Ahlers ST, Cristian A. Blast-induced mild traumatic brain injury. In: Riggio S, editor. Psychiatric Clinics of North America. New York, 2010.

Mann SL, Hazlett EA, Byne W, Buchsbaum MS, Cohen B, Mitsis EM, Siever LJ. Anterior and posterior cingulate cortex volume in healthy adults: Effects of aging and sex differences. Brain Research 2011; 1401: 18-29.

Van Dam NT, Sano MC, Mitsis EM, Grossman H, Gu X, Park Y, Hof P, Fan J. Functional neural correlates of attentional deficits in amnestic mild cognitive impairment. PLoS One 2013; 8(1).

Gandy S, Ikonomovic M, Mitsis EM, Ahlers S, Elder G, Barth J, Stone J, DeKosky ST. Chronic Traumatic Encephalopathy: Clinical-Biomarker Correlations and Current Concepts in Pathogenesis [review]. Molecular Neurodegeneration 2014;.

Mitsis EM, Bender H, Kostakoglu L, Machac J, Martin J, Woehr J, Sewell MC, Aloysi A, Goldstein MA, Li C, Sano M, Gandy S. A Consecutive Case Series Experience with [18F] Florbetapir PET Imaging in an Urban Dementia Center: Impact on Quality of Life, Decision Making, and Disposition [review]. Molecular Neurodegeneration 2014;.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Mitsis did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at Patients may wish to ask their physician about the activities they perform for companies.

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