Prior to joining the faculty of Mount Sinai School of Medicine in 2005 as Professor of Medicine and Chief of the Division of Endocrinology, Diabetes and Bone Disease, Dr. LeRoith was Chief of the Diabetes Branch at the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. This is the largest program devoted to the study of diabetes within the intramural program of the NIH. He has published over 500 original research papers, reviews and editorials and edited a number of books on Diabetes and IGF-related topics. He is also the senior editor of a major textbook on Diabetes, now in its third edition.
In the News
Dr. LeRoith discusses awareness and prevention of diabetes in The Daily News feature The Daily Check Up. View the PDF.
PhD, University of Cape Town
, The Middlesex Hospital
Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D, , . Insulin-like growth-factor-1 protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.. Cell Death Differ 2008; 15: 1304-1317.
Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D. The role of insulin receptor signaling in zebrafish embryogenesis.. Endocrinology 2008; 149: 5996-6005.
Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.. FASEB J 2009; 23: 709-719.
Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen K, LeRoith D. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.. Bone 2009; 44: 648-655.
Kawashima Y, Chen H, Sun H, Lann D, Hajjar RJ, Yakar S, LeRoith D, . Apolipoprotein E deficiency abrogates insulin resistance in a mouse model Type 2 diabetes mellitus.. Diabetologia 2009 Jul; 52(7): 1434-1441.
Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, Digirolamo DJ, Kopchick JJ, LeRoith D, Trucco M, Sperling MA. Liver-specific deletion of the growth hormone receptor reveals essential role of GH signaling in hepatic lipid metabolism.. J Biol Chem 2009 Jul; 284(30): 19937-19944.
Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D. Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-1 receptors is required for oncogene activation and tumour initiation.. Oncogene 2009 Oct; 28(39): 3477-3486.
Wu Y, Sun H, Yakar S, LeRoith D, . Elevated levels of insulin-like growth factor (IGF)-1 in serum resuce the severe growth retardation of IGF-1 null mice.. Endocrinology 2009; 150: 4395-4403.
Novosyadlly R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, Kurshan N, Mejia W, Santopietro S, Yakar S, Wood TL, LeRoith D. Insulin-mediated acceleration of breast cancer development and progression in a non-obese model of type 2 diabetes.. Cancer Research 2010 Jan; 70(2): 741-751.
Fierz Y, Novosyadlly R, Vijayakumar A, LeRoith D, . Insulin sensitizing therapy abrogates accelerated breast cancer progression in a mouse model of type 2 diabetes.. Diabetes 2010; 59: 686-693.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. LeRoith during 2015 and/or 2016. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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