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Christina Wyatt

  • ASSOCIATE PROFESSOR Medicine, Nephrology
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Specialty

Certifications

  • Nephrology

Education

  • MD, Duke University

  • BA, Duke University

  • MS, Columbia University
    Mailman School of Public Health

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Fellowship, Nephrology
    Mount Sinai Hospital

Biography

Research

Dr. Wyatt is actively involved in clinical care and clinical research in HIV-related kidney disease. Her research has focused on defining the epidemiology of kidney disease among HIV-infected individuals, including those with comorbid risk factors such as Hepatitis C co-infection and diabetes. She has established collaborations with several large HIV cohorts, and is the director of the clinical core of a longstanding P01 investigating the pathogenesis of HIV-associated nephropathy. She is also the PI of an R01 evaluating the renal safety of oral pre-exposure prophylaxis to prevent HIV infection.

Publications

Wyatt CM, Morgello S, Katz-Malamed R, Wei C, Klotman ME, Klotman PE, D'Agati VD. The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy. Kidney international 2009 Feb; 75(4).

Paragas N, Nickolas TL, Wyatt C, Forster CS, Sise M, Morgello S, Jagla B, Buchen C, Stella P, Sanna-Cherchi S, Carnevali ML, Mattei S, Bovino A, Argentiero L, Magnano A, Devarajan P, Schmidt-Ott KM, Allegri L, Klotman P, D'Agati V, Gharavi AG, Barasch J. Urinary NGAL marks cystic disease in HIV-associated nephropathy. Journal of the American Society of Nephrology : JASN 2009 Aug; 20(8).

Wyatt CM, Hoover DR, Shi Q, Seaberg E, Wei C, Tien PC, Karim R, Lazar J, Young MA, Cohen MH, Klotman PE, Anastos K. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. Journal of acquired immune deficiency syndromes (1999) 2010 Sep; 55(1).

Wyatt CM, Shi Q, Novak JE, Hoover DR, Szczech L, Mugabo JS, Binagwaho A, Cohen M, Mutimura E, Anastos K. Prevalence of kidney disease in HIV-infected and uninfected Rwandan women. PloS one 2011; 6(3).

Medapalli RK, Parikh CR, Gordon K, Brown ST, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Chang CC, Justice AC, He JC, Wyatt CM. Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: data from the Veterans Aging Cohort Study. Journal of acquired immune deficiency syndromes (1999) 2012 Aug; 60(4).

Mocroft A, Neuhaus J, Peters L, Ryom L, Bickel M, Grint D, Koirala J, Szymczak A, Lundgren J, Ross MJ, Wyatt CM. Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults. PloS one 2012; 7(7).

Inker LA, Wyatt C, Creamer R, Hellinger J, Hotta M, Leppo M, Levey AS, Okparavero A, Graham H, Savage K, Schmid CH, Tighiouart H, Wallach F, Krishnasami Z. Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals. Journal of acquired immune deficiency syndromes (1999) 2012 Nov; 61(3).

Estrella MM, Wyatt CM, Pearce CL, Li M, Shlipak MG, Aouizerat BE, Gustafson D, Cohen MH, Gange SJ, Kao WH, Parekh RS. Host APOL1 genotype is independently associated with proteinuria in HIV infection. Kidney international 2013 Oct; 84(4).

Wyatt CM, Schwartz GJ, Owino Ong'or W, Abuya J, Abraham AG, Mboku C, M'mene LB, Koima WJ, Hotta M, Maier P, Klotman PE, Wools-Kaloustian K. Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance. PloS one 2013; 8(8).

Wyatt CM, Schwartz GJ, Owino Ong'or W, Abuya J, Abraham AG, Mboku C, M'mene LB, Koima WJ, Hotta M, Maier P, Klotman PE, Wools-Kaloustian K. Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance. PloS one 2013; 8(8).

Wyatt CM, Kitch D, Gupta SK, Tierney C, Daar ES, Sax PE, Ha B, Melbourne K, McComsey GA. Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine. Journal of acquired immune deficiency syndromes (1999) 2014 Sep; 67(1).

Gupta SK, Anderson AM, Ebrahimi R, Fralich T, Graham H, Scharen-Guivel V, Flaherty JF, Fortin C, Kalayjian RC, Rachlis A, Wyatt CM. Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients. PloS one 2014; 9(3).

Lucas GM, Ross MJ, Stock PG, Shlipak MG, Wyatt CM, Gupta SK, Atta MG, Wools-Kaloustian KK, Pham PA, Bruggeman LA, Lennox JL, Ray PE, Kalayjian RC. Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014 Nov; 59(9).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Wyatt during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Other Activities: Examples include, but are not limited to, committee participation, data safety monitoring board (DSMB) membership.

  • BioCryst Pharmaceuticals, Inc.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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