AB, Princeton University
PhD, Harvard Medical School
, MGH Cancer Center/Harvard and UC Berkeley
Cancer Biology [CAB], Developmental and Stem Cell Biology [DSCB]
Kimmel Scholar Award
Yan H, Chin ML, Horvath EA, Kane EA, Pfleger CM. Impairing ubiquitination by mutation in Drosophila E1 promote cell autonomous and non-autonomous Ras/ERK activation in vivo. Journal of Cell Science; In Press.
Pfleger CM, Harvey KF, Yan H, Hariharan IK. Mutation of the Ubiquitin Activating Enzyme Uba1 causes tissue overgrowth in Drosophila. Fly 2007;(1): 95-105.
Mills K, Harvey KF, Daish T, Pflege CM, Hariharan IK, Kumar S. The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol 2006;(172): 809-815.
Chuang LC, XN ZH, Herrera CR, Tseng HM, Pfleger CM, Block K, Yew PR. The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis. J Biol Chem 2005;(280): 35290-35298.
Pfleger CM, Dellale I, Buff E, Lueras P, Hariharan IK. Mutations in the Drosophila orthologs of the F-actin capping protein-and-subunits cause actin accumulation and subsequent retinal degeneration. Genetics 2005;(171): 1757-1765.
Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003;(114): 457-467.
Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. PNAS U S A 2003;(100): 3925-3929.
Pfleger CM, Lee E, Kirschner MW. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes and Developm 2001;(15): 2396-2407.
Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes and Development 2001;(15): 1759-1764.
Pfleger CM, Kirschner MW. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes and Development 2000;(14): 655-655.
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Dr.Pfleger did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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