Dr. Schroppel has recently been appointed the Medical Directory of Transplant Nephrology.
Mentored Clinical Scientist Development Award (K08)
National Institute of Health
Louis R. Wasserman Medical Scholar Career Development Award
Norman S. Coplon Grant, Satellite Research Award
American Society of Transplant Surgeons (ASTS) Vanguard Prize
''Jan Brod'' research award
University of Hannover, Germany
Fresenius medical thesis research award
University of Ulm, Germany
The role of donor-derived chemokines in islet transplantation
A major challenge of pancreatic islet transplantation is the protection of the already putatively marginal islet cell mass. Our data demonstrate that islets have the capacity to behave in a similar manner to cells of the immune system, recruiting leukocytes from the blood stream. The hypothesis is that islet-derived mediators directly or indirectly affect islet engraftment, function and viability, and serve to further amplify the adaptive immune response. The goals are to characterize the innate immune response to specific stimuli in islet transplantation and to identify therapeutic strategies to improve islet transplant engraftment and survival.
Genetic studies in Transplantation
Despite a marked improvement in renal transplant rejection rates over the last decade, the improvement in long-term allograft survival remains modest. Recent advances from the Human Genome Project have identified numerous regions of genetic variability, both single-nucleotide polymorphisms (SNP's) and microsatellites regions, within genes relevant to transplantation. Delayed graft function (DGF) is a form of acute renal failure resulting in post-transplantation oliguria, increased allograft immunogenicity and decreased long-term survival. Our ongoing research is based on the following two hypothesis: (1) The susceptibility to DGF is modified by inherited genetic polymorphisms that alter the level of response in genes that are known to modify the response to tissue injury; (2) Distinct gene expression patterns can be identified in the transplanted allograft that can predict DGF and that can reliably discriminate complex mechanisms of DGF.
Fischereder M, Schroppel B. The role of chemokines in acute renal allograft rejection and chronic allograft nephropathy. Frontiers in Bioscience;: in press.
Zang W, Lin M, Kalache S, Zhang N, Kruger B, Waaga-Gasser AM, Grimm M, Hancock W, Heeger P, Schroppel B, Murphy B. Inhibition of the Alloimmune Response Through the Generation of Regulatory T Cells by a MHC Class II-Derived Peptide. J Immunol 2008; 181: 7499-7506.
Akalin E, Dinavahi R, Friedlander R, Ames S, de Boccardo G, Schroppel B, Bhaskaran M, Lerner S, Fotino M, Murphy B, Bromberg JS. The addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies. Clin J Am Soc Nephrol 2008; 3(4): 1160-1167.
Akalin E, Dinavahi R, Dikman S, de Boccardo G, Friedlander R, Schroppel B, Sehgal V, Bromberg JB, Heeger P, Murphy B. Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining. Clin J Am Soc Nephrol 2007; 2(6): 1261-1267.
Ommen ES, Schroppel B, Kim JY, Gaspard G, Akalin E, de Boccardo G, Sehgal V, Lipkowitz M, Murphy B. Routine use of ambulatory blood pressure monitoring in potential living kidney donors. Clin J Am Soc Nephrol 2007; 2(5): 1030-1036.
Chen D, Zhang N, Fu S, Schroppel B, Guo Q, Xu J, Garin E, Lira SA, Bromberg JS. CD4+CD25+ T regulatory cells inhibit the islet innate immune response and promote islet engraftment. Diabetes 2006; 55: 1011-1021.
Zang W, Kalache S, Lin M, Schroppel B, Murphy B. MHC class II mediated apoptosis by a non-polymorphic MHC class II peptide proceeds by activation of proteinase C. Am Soc Nephrol 2005; 16(12): 3661-6668.