- PROFESSOR Neurology
- ASSOCIATE PROFESSOR Structural and Chemical Biology
Neurology, American Board of Psychiatry and Neurology
- Central Pattern Generator
- Comparative Anatomy
- Computational Neuroscience
- Computer Simulation
- Extracellular Unit Recording
- Eye Movements
- Inner Ear
- Mathematical Modeling of Biomedical Systems
- Motor Control
- Neural Code
- Neural Networks
- Neuromuscular System
- Postural Control
- Space Flight
- Structural Biology
- Theoretical Neuroscience
MD, New York University School of Medicine
Internship, Internal Medicine
Mount Sinai Hospital
New York University School of Medicine
ResearchSpecific Clinical/Research Interest:
Vestibular control of natural movement in animals and humans, on earth and in space
Current Students: Julia Eron
Postdoctoral Fellows: Yasuhiro Osaki, Yongqing Ziang, Danje Zhu, Hamish Macdougall
Research Personnel: Juan Martinez, Sergey Tarasenko, Dmitri Ogorodnikov
Summary of Research Studies:
Studies in our laboratory are dedicated toward understanding the neural basis for spatial orientation in humans and animals, on Earth and in space. Techniques utilized include precise recordings of head, eye, body, and limb movements in three-dimensional space while humans and monkeys perform natural linear and circular locomotion. Also ongoing are behavioral (eye movement) studies on animals and humans utilizing multiaxis vestibular stimulators. Single unit recordings are done in the brainstem and cerebellum of animals performing behavioral tasks or in response to linear and angular acceleration. Multiunit recordings of muscle sympathetic nerve activity are utilized in humans to study vestibulosympathetic reflexes. Also in progress are studies utilizing centrifugation and eye movement recordings of astronauts before, during and after space flight. Studies on treatment of motion sickness in humans are also in progress. Mathematical modeling is an integral part of the approach to describing how neural organizations in the brainstem and cerebellum code spatial orientation.
Cohen B, Xiang Y, Yakushin SB, Kunin M, Raphan T, Minor LB, Della Santina CC. Effect of canal plugging on quadrupedal locomotion in monkey. Ann. NY Acad Sci 2008; In press: 1431.
Eron JN, Cohen B, Raphan T, Yakushin SB. Adaptation of orientation vec tors of otolith-related central vestibular neurons to gravity. J Neurophysiol 2008; 100(3): 1686-1690.
Osaki Y, Kunin M, Cohen B, Raphan T. Relative contribution of walking velocity and stepping frequency to the neural control of locomotion. Exp Brain Res 2008; 185: 121-135.
Xiang Y, John P, Yakushin SB, Kunin M, Raphan T, Cohen B. Dynamics of quadrupedal locomotion of monkeys: implications for central control. Exp Brain Res 2007; 177(4): 551-572.
Cho C, Osaki Y, Kunin M, Olanow W, Cohen B, Raphan T. Kinematics and dynamics of Parkinson gait. Conf Proc IEEE Eng Med Biol Soc 2006; 1: 1228-1231.
Yakushin SB, Xiang Y, Raphan T, Cohen B. Spatial distribution of gravity dependent gain changes in the vestibulo-ocular reflex (DOI, 10.1152/jn.01269.2004). J Neurophysiol 2005;.
Moore ST, Cohen B, Raphan T, Berthoz A, Clement G. Spatial orientation of optokinetic nystagmus and visual tracking during orbital space flight. Exp Brain Res 2005; 160: 38-59.
Dai M, Kunin M, Raphan T, Cohen B. The relation of motion sickness to the spatial-temporal properties of velocity storage. Exp. Brain Res 2003; 151: 173-189.
Raphan T, Cohen B. The vestibulo-ocular reflex in three dimensions. Exp. Brain Res 2002; 145: 1-27.
Kaufmann H, Biaggioni I, Voustianiouk A, Diedrich A, Costa F, Clarke R, Gizzi M, Raphan T, Cohen B. Vestibular control of sympathetic activity; an otolith-sympathetic reflex in humans. Exp. Brain Res 2002; 143: 463-469.
Cho C, Kunin M, Kudo K, Osaki Y, Olanow CW, Cohen B, Raphan T. Frequency-velocity mismatch: a fundamental abnormality in parkinsonian gait. Journal of neurophysiology 2010 Mar; 103(3).
Dai M, Raphan T, Cohen B. Prolonged reduction of motion sickness sensitivity by visual-vestibular interaction. Experimental brain research 2011 May; 210(3-4).
Cohen B, Martinelli GP, Raphan T, Schaffner A, Xiang Y, Holstein GR, Yakushin SB. The vasovagal response of the rat: its relation to the vestibulosympathetic reflex and to Mayer waves. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jul; 27(7).
Osaki Y, Kunin M, Cohen B, Raphan T. Relative contribution of walking velocity and stepping frequency to the neural control of locomotion. Experimental brain research 2008 Feb; 185(1).
Dai M, Cohen B, Smouha E, Cho C. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome. Frontiers in neurology 2014; 5.
Raphan T, Matsuo V, Cohen B. Velocity storage in the vestibulo-ocular reflex arc (VOR). Experimental brain research 1979 Apr; 35(2).
Kaufmann H, Biaggioni I, Voustianiouk A, Diedrich A, Costa F, Clarke R, Gizzi M, Raphan T, Cohen B. Vestibular control of sympathetic activity. An otolith-sympathetic reflex in humans. Experimental brain research 2002 Apr; 143(4).
Eliazian M, Shahlapour A, Tamiji Y. Control of Paraspidodera unicinata in guinea-pigs with levamisole. Laboratory animals 1975 Oct; 9(4).
Dai M, Kunin M, Raphan T, Cohen B. The relation of motion sickness to the spatial-temporal properties of velocity storage. Experimental brain research 2003 Jul; 151(2).
Moore ST, Cohen B, Raphan T, Berthoz A, Clément G. Spatial orientation of optokinetic nystagmus and ocular pursuit during orbital space flight. Experimental brain research 2005 Jan; 160(1).
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Annenberg Building Floor 21 Room 21-74 (Lab: Animal)
1468 Madison Avenue
New York, NY 10029
Atran Berg Laboratory Building Room 105 (Lab: Human)
1428 Madison Avenue
New York, NY 10029