Cancer, Computational Biology, Drug Design and Discovery, Membrane Proteins/Channels, Protein Structure/Function, Transporters
Multi-Disciplinary Training Areas
Biophysics and Systems Pharmacology [BSP], Cancer Biology [CAB]
BSc, Tel Aviv University
PhD, Columbia University
Postdoctoral Training, University of California, San Francisco
Our lab focuses on the development and application of computational tools to annotate the functions of proteins. The two major research areas of our group include:
1. Structure-based drug design for membrane transporters. Our group characterizes cancer-related membrane transporter proteins, using a structure-based discovery approach, including homology modeling and virtual ligand screening, in collaboration with experimental labs. We rationally design novel chemical tools to study transporters’ role in cancer metabolism pathways, with a long-term goal of developing drugs against these potential cancer drug targets.
2. Structural bioinformatics. The lab works on developing and applying sequence-based and structure-based methods to predict different features of proteins using various machine-learning techniques. We analyze the predicted features of proteins in the context of networks and proteomes, to characterize protein functions.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Schlessinger has not yet completed reporting of Industry relationships.
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