, Radiobiological Institute, TNO (Rijswiik, The Netherlands)
, University of Washington (Seattle, WA)
PhD, University of Naples (Naples, Italy)
PhD, University of Naples (Naples, Italy)
International Journal Hematology
"Mouse models of Myelofibrosis"
The scope of this project is to exploit the Gata1low mouse model to detail the pathobiological pathway leading to development of increased stem/progenitor cell trafficking and extramedullary hematopoiesis in myleofibrosis
New York State Star Program:
"Personalized Therapies for Sickle Cell Disease and Thalassemia."
The scope of this project is to develop in vitro assays to predict the response to therapy with histone deacetylase inhibitors of sickle cell and thalassemia patients.
Member of the Program for Excellency in Training "Eurythron" European Community
The scope of this project is to establish a multicenter excellence training program in Experimental Hematology
Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio M, Orkin SH, Migliaccio AR. The hypomorphic Gata1low mutation alters the proliferation/ differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 2007; 109: 1460-1471.
Martelli F, Ghinassi B, Panetta B, Alfani E, Gatta V, Pancrazzi A, Bogani C, Vannucchi AM, Paoletti F, Migliaccio G, Migliaccio AR. Variegation of the phenotype induced by the GATA-1low mutation in mice of different genetic background. Blood 2005; 106: 4102-4113.
Vannucchi AM, Bianchi L, Paoletti F, Pancrazi A, Torre E, Nishikawa M, Zingariello M, Di Baldassarre A, Rana RA, Lorenzini R, Alfani E, Migliaccio G, Migliaccio AR. A patho-biological pathway linking thrombopoietin, GATA-1 and TGF-B1 in the development of myelofibrosis. Blood 2005; 105: 3493-3501.
Centurione L, Di Baldassarre A, Zingariello M, Bosco D, Gatta V, Rana RA, Langella V, Di Virgilio A, Vannucchi AM, Migliaccio AR. Increased and pathological emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice. Blood 2004; 104: 3573-3579.
Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Migliaccio G, Orkin SH. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-low mouse mutant. J Exp Med 2003; 197: 281-296.
Vannucchi A, Bianchi L, Cellai C, Paoletti F, Rana RA, Lorenzini R, Migliaccio G, Migliaccio AR. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (Gata-1low mice). Blood 2002; 100: 1123-1132.
Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell dose. Blood 2000; 96: 2717-2722.
Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR, Berkowitz RL, Cabbad M, Dobrilla L, Taylor P, Stevens C. Initial results of the placental/umbilical cord blood program for unrelated bone marrow reconstitution. New Engl J Med 1998; 339: 1565-1577.
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Dr. Migliaccio has not yet completed reporting of Industry relationships.
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