Aneel K Aggarwal | Mount Sinai

About Me

Dr. Aggarwal is an internationally recognized structural biologist, who earned his PhD in biophysics at Kings College, University of London, in 1984. From 1985 to 1987, Dr. Aggarwal participated in a NATO research fellowship and was also a postdoctoral fellow in the Department of Biochemistry and Molecular Biology at Harvard University. He then became an Assistant Professor at Columbia University before joining the Mount Sinai Medical School. He is currently a Professor in the Department of Structural & Chemical Biology and holds an Endowed Chair as the Mount Sinai Professor in Structural Biology.

Dr. Aggarwal is a member of the Cancer Mechanisms Program at The Tisch Cancer Institute.

Language

English

Position

PROFESSOR | Pharmacological Sciences, PROFESSOR | Oncological Sciences

Research Topics

DNA Repair, DNA Replication, Structural Biology, Transcription Factors, Translation

Multi-Disciplinary Training Areas

Cancer Biology [CAB], Disease Mechanisms and Therapeutics (DMT), Genetics and Genomic Sciences [GGS]

Education

PhD, Kings College, University of London

, Harvard University

Awards

2012

Dean’s Award for Excellence in Basic Science Research

2010

Faculty Council Award for Academic Excellence

2007

Mount Sinai Professor in Structural Biology (Endowed Chair)

1995

The Doctor Harold and Golden Lamport Award for Excellence in Basic Science Research

1990

Irma T. Hirschl Career Scientist Award

1990

Basil O'Connor Starter Scholar Research Award

1985

The North Atlantic Treaty Organization (NATO) Research Fellowship

1985

EMBO Long-term Fellowship (Declined)

1981

Science and Engineering Research Council (SERC) of Great Britain Studentship

Research

We use a variety of structural tools to uncover how enzymes, and transcription and translation regulators interact with nucleic acids to affect cellular development and disease outcome. We study how such proteins locate, bind, and move on their DNA or RNA sites, and, then use that knowledge to create enzymes with new specificities and obtain a molecular understanding for how genes are regulated. We are also interested in learning how cells cope with the effects of DNA damage. In particular, we investigate how a set of specialized DNA polymerases can bypass DNA damage during replication and how mutations in them can lead to cancer.

Laboratory website: http://www.protdnarna.org