HealthDay - “Scientists Spot New Brain 'Pathways' Possibly Tied to Alzheimer's”
Doctors have long known that people with genes that produce a cholesterol-transporter molecule called APOE4 are at especially high risk for Alzheimer's disease. Researchers say they've discovered key molecular pathways at work inside brain cells that appear to be altered by the presence of APOE4. "The role of APOE4 in enhancing Alzheimer's risk has been a vexing problem for 20 years. The gene increases amyloid buildup in mouse models but no consistent molecular or cellular explanation has emerged," explained Sam Gandy, MD, Director of The Mount Sinai Center for Cognitive Health.