CEHCNY Research and Publications 

The Centers in the CEHCNY network participates in various research activities with the goal of studying the environmental effects on children’s health and discovering strategies to prevent adverse outcomes. 

The Mount Sinai Health System’s Queens Vanguard Center is one of seven sites selected nationally to lead the implementation of the National Children’s Study. This long-term research project is following 100,000 American children from conception to age 21 in an effort to discover the factors in the environment that promote good health, as well as those that contribute to disease, among the nation’s children.

Look Before You LEAP is an exciting collaborative project headed by the Huntington Breast Cancer Action Coalition Inc. (HBCAC). The Look Before You LEAP is an educational program offering environmental health information in a manner that is non-threatening, age-appropriate and fun for children and families. LEAP stands for Lead, Endocrine Disruptors, Air Pollution, and Pesticides, four well established environmental toxins. The program encourages dialogue about hazardous substances and provides safer alternative choices. The LEAP tote includes fun and interactive materials, such as a game board, activity coloring book and reference cards to help families understand the role toxic chemicals play in human health. LEAP’s goal is to promote healthy behaviors and lifestyle practices enabling parents to make safer purchasing decisions.

Current research projects at Children’s Environmental Health Center of the Hudson Valley at New York Medical College  include: 

Relationship between atmospheric and weather conditions and pulmonary function in children with asthma. This is a large epidemiological study examining the relationship between temperature, humidity and barometric pressure and measurements of lung function obtained in children with asthma. 

Environmental Tobacco Smoke and pulmonary function tests in young children with asthma: Impulse Oscillometry and Airway Reactivity. This study investigates the effects of exposure to environmental tobacco smoke on lung function and airway reactivity in young children. 

Airway Inflammation and Environmental Tobacco Smoke: Cytokines in Exhaled Breath Condensate. This is a basic laboratory study designed to help unravel the biochemical pathways that link environmental tobacco smoke to lung disease in children. In this study, exhaled breath condensates are collected to test for signs of inflammation. 

Nitrooxidative Stress: The effects of Environmental Tobacco Smoke on airway inflammation and trans-arachidonic acid mediators in asthma. This study is a collaborative effort of the staff of the Children's Environmental Health Center and the basic scientists at New York Medical College . The purpose of this study is to better understand exactly why exposure to second hand smoke is so bad for children with asthma. 

The relationship between Exposure to Environmental Tobacco Smoke and Gastroesophageal Reflux in children with Asthma (Substudy of SARCA: The Study of Acid Reflux in Children with Asthma, a multicenter placebo-controlled trial in children with asthma.) This substudy is designed to further analyze the role of exposure to environmental tobacco smoke which is known to worsen both asthma and gastroesophageal reflux. The interaction between these three problems is the focus of this research. 

The Study of Soy Supplementation in Asthma. This study is to test the hypothesis that patients with symptomatic asthma have improved lung function when treated with a soy isoflavone dietary supplement.

Current research projects at the Rochester Regional Children Environmental Center at the University of Rochester include:

  • The Impact of a Neurofeedback Program on Primary Grade Reading Scores of Children with Lead Poisoning: This study utilizes a retrospective cohort design. It investigates whether primary-grade children who have learning disability due to lead exposure have improved reading after receipt of a computerized neurofeedback program.
  • Modulation of antibody responses to human HPV vaccine by lead exposure: This study explores the association between lead exposure and humoral immunity.
  • The Effect of Environmental Lead Exposure on Bone Density in Children, Adolescents & Adults: This study investigates the association between lead exposure and bone density. 

Publications penned by Rochester’s Children Environmental Center include: 

Eisenberg KW, van Wijngaarden E, Fisher SG, Fernandez ID, Campbell JR, Cochran J, Geltman PL. Blood Lead Levels of Refugee Children Resettled in Massachusetts, 2000-2007. Am J Public Health. Published online ahead of print November 18, 2010: e1–e7. doi:10.2105/AJPH.2009. 184408

van Wijngaarden E, Campbell JR, Cory-Slechta DA. Bone lead levels are associated with measures of memory impairment in older adults. Neurotoxicology. 2009;30:572-580. 

Campbell JR, Auinger P. The association between blood lead levels and osteoporosis among adults - Results from the third National Health and Nutrition Examination Survey (NHANES III). Env Hlth Persp. 2007;115:1018-1022. 

Campbell JR, Puzas JE, Novotny L. The association between environmental lead exposure and bone density in children. Env Hlth Persp. 2004;112:1200-1203. Campbell JR, Toribara TY. Hair-root lead to screen for lead toxicity. J Trace Elem Exp Med. 2001;14:69-72. 

Campbell J, Moss M, Raubertas R. The association between caries and childhood lead exposure. Env Hlth Persp. 2000;108(11):1099-1102 

Campbell JR, Schaffer SJ. Predicting the outcome of the CaNa2EDTA challenge test in children with moderately elevated blood lead levels. Env Hlth Persp. 1999;107(6):437-440 

Schaffer SJ, Campbell JR, Szilagyi PG, Weitzman M. Lead screening practices of pediatric residents. Arch Pediatr Adolesc Med. 1998;152:185-189 

Campbell JR, Paris M, Schaffer SJ. A comparison of screening strategies for elevated blood lead levels. Arch Pediatr Adolesc Med. 1996;150:1205-1208 (Letter: Arch Pediatr Adolesc Med. 1997;151:636) 

Campbell JR, Schaffer SJ, Szilagyi PG, O'Connor KG, Briss P, Weitzman M. Blood lead screening practices among US pediatricians. Pediatrics. 1996;98:372-377 

Campbell JR, McConnochie KM, Weitzman M. Lead screening among high-risk urban children: Are the 1991 Centers for Disease Control and Prevention guidelines feasible? Arch Pediatr Adolesc Med. 1994;148:688-693.