Definition

Mild cognitive impairment–amnestic type (MCI-AT) is mild, repeated memory loss. It lies between the normal memory loss of aging and the more serious conditions of dementia and Alzheimer’s disease (AD). MCI-AT only involves problems with memory. Dementia and Alzheimer's involve loss of other cognitive abilities, such as:

• Learning
• Reasoning
• Making decisions
• Problems with confusion, language, and attention

People with MCI-AT who are over age 65 have a higher chance of developing dementia and Alzheimer's. However, many people with MCI-AT never develop these disorders. Some even return to normal.

Some Areas of the Brain Affected by Dementia and Alzheimer's Disease

© 2011 Nucleus Medical Media, Inc.

Causes

The causes are not clear. However, genetic factors may be a cause.

Risk Factors

These risk factors increase your chance of developing MCI-AT. Tell your doctor if you have any of these risk factors:

• Age: 65 and older
• Family history of MCI-AT, dementia, or Alzheimer's
• Medical conditions, such as high blood pressure, heart disease, diabetes, stroke, head injury, depression, anxiety, infections
• Being overmedicated
• Substance abuse

Research also suggests that these may be risk factors for MCI-AT:

• Lack of physical activity
• Lack of social contact
• Low educational level
• Excessive response to stress
• Poor nutrition and lack of vitamins
• Exposure to toxins

Symptoms

The main symptom is frequent, ongoing memory loss beyond what is normally expected for your age. That means having more than small lapses of memory. If you have MCI-AT, you may:

• Remember much less of what you have just read or seen than people who have only the normal memory changes of aging
• Take longer to recall information

Diagnosis

The doctor will ask about your symptoms and medical history. She will also:

• Do a physical exam
• Tests your cognitive skills, including memory
• Do additional tests if needed, such as:
  • Blood tests
  • MRI scan —a test that uses magnetic waves to make pictures of structures inside the body
  • Lumbar puncture (spinal tap)—removal of a small amount of fluid that surrounds the brain and spinal cord

The doctor may also talk with family members and caregivers. If you have this condition, you should have your cognitive abilities tested regularly.

Treatment

Treatment is focused:

• Preventing, or at least slowing down, further loss of memory and other cognitive abilities
• Preventing dementia and Alzheimer's disease

Researchers are currently studying the effects that several medicines may have on slowing cognitive decline. Examples include donepezil , vitamin E, galantamine (Razadyne), among other medicines. In some cases, low doses of lithium may be prescribed.

Prevention

The following are being studied as ways to reduce the risk of cognitive decline:

• Managing medical conditions that may lead to MCI-AT, especially high blood pressure
• Getting treatment for depression and hypothyroidism
• Staying mentally active by doing things like memory exercises, crossword puzzles, reading, taking classes
• Getting regular exercise
• Participating in social activities
• Reducing stress
• Getting help for emotional problems
• Eating a healthy diet