Reye syndrome is sudden (acute) brain damage and liver function problems that do not have a known cause.
This syndrome has occurred in children who were given aspirin when they had chickenpox or the flu. Reye syndrome has become very rare because aspirin is no longer recommended for routine use in children.
Reye syndrome is most often seen in children ages 4 to 12. Most cases that occur with chickenpox are in children ages 5 to 9. Cases that occur with the flu are usually in children ages 10 to 14.
Children with Reye syndrome get sick very suddenly. The syndrome often begins with vomiting, which lasts for many hours. The vomiting is quickly followed by irritable and aggressive behavior. As the condition gets worse, the child may be unable to stay awake and alert.
Other symptoms of Reye syndrome:
Other symptoms that can occur with this disorder include:
The following tests may be used to diagnose Reye syndrome:
There is no specific treatment for this condition. The health care provider will monitor the pressure in the brain, blood gases, and blood acid-base balance (pH).
Treatments may include:
How well a person does depends on the severity of any coma, as well as other factors.
The outcome for those who survive an
Complications may include:
When untreated, seizures and coma may be life threatening.
Go to the emergency room or call the local emergency number (such as 911) immediately if your child has confusion, lethargy, or other mental changes.
Never give a child aspirin unless told to do so by your doctor.
When a child must take aspirin, take care to reduce the child's risk of catching a viral illness, such as the flu and chickenpox. Avoid aspirin for several weeks after the child has received a varicella (chickenpox) vaccine.
Note: Other over-the-counter medicines, such as Pepto-Bismol and substances with oil of wintergreen also contain aspirin compounds called salicylates. DO NOT give these to a child who has a cold or fever.
Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:310-311.
Ferri FF. Reye's syndrome. In: Ferri FF, ed. Ferri's Clinical Advisor 2011. 1st ed. Philadelphia, PA: Elsevier Mosby; 2010:section 1.
Goetz CG. Textbook of Clinical Neurology. 2nd ed. St. Louis, MO: WB Saunders; 2003:656-657.
Johnston MV. Encephalopathies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 591.
Michaels MG. Reye syndrome. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. Philadelphia, PA: Churchill Livingstone; 2003:chap 50.
Noble J. Textbook of Primary Care Medicine. 3rd ed. St. Louis, MO: Mosby; 2001:46-47.
Last reviewed on: 8/30/2014
Reviewed by: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.