Cancer - lung
Lung cancer is cancer that starts in the lungs.
The lungs are located in the chest. When you breathe, air goes through your nose, down your windpipe (trachea), and into the lungs, where it flows through tubes called bronchi. Most lung cancer begins in the cells that line these tubes.
There are 2 main types of lung cancer:
If the lung cancer is made up of both types, it is called mixed small cell/large cell cancer.
If the cancer started somewhere else in the body and spreads to the lungs, it is called metastatic cancer to the lung.
Cancer can affect just about any part of the body, from the colon to the pancreas. Some cancers grow quickly, while others grow more slowly and are easier to treat. But of all the different cancers out there, one of the deadliest is lung cancer. Let's talk today about lung cancer.Cancer starts when cells begin to grow uncontrollably and form tumors. In the case of lung cancer, the tumors start in the lungs. Sometimes cancer starts somewhere else in the body and then spreads to the lungs. In that case, it's called metastatic cancer to the lung. "Metastatic" means disease that has spread.There are two types of lung cancer. The most common, and slower-growing form is non-small cell lung cancer. The other, faster-growing form is called small cell lung cancer. The most common way to get lung cancer is to smoke cigarettes. The more cigarettes you smoke and the earlier you start smoking, the greater your risk is. Even being around someone who smokes and breathing in the secondhand smoke from their cigarettes increases your risk of getting lung cancer. Even though smoking makes you much more likely to get lung cancer, you don't have to smoke or be exposed to smoke to get the disease. Some people who have lung cancer never lit up a cigarette in their life. They have been exposed to cancer-causing substances like asbestos, diesel fumes, arsenic, radiation, or radon gas. Or, they may not have had any known lung cancer risks.The most common signs of lung cancer are a cough that won't go away, chest pain, shortness of breath, weight loss, and fatigue. But just because you have these symptoms it doesn't mean that you have don't have lung cancer. These can also be signs of other conditions, like asthma or a respiratory infection. If you do have these symptoms, see your doctor. A chest x-ray, MRI, or CT scan can view the inside of your lungs to look for signs of cancer or other diseases. What happens if you do have lunch cancer?Doctors divide lung cancer into stages. The higher the stage, the more the cancer has spread. For example, a stage 1 cancer is small and hasn't spread outside of the lungs. A stage 4 cancer has spread to the other organs, such as the kidneys or brain. Depending upon the type and stage of your lung cancer, you may need surgery to remove part or all of your lung. Or, your doctor may recommend radiation or chemotherapy to kill cancer cells.If you have lung cancer, how well you do depends upon the stage of your disease and the type of lung cancer that you have. Early-stage cancers have the highest survival and cure rates. Late-stage cancers are harder to treat. Because lung cancer can be so deadly, prevention is key. The most important that thing you can do is to stop smoking, and avoid being around anyone who does smoke.
Lung cancer is the deadliest type of cancer for both men and women. Each year, more people die of lung cancer than of breast, colon, and prostate cancers combined.
Lung cancer is more common in older adults. It is rare in people under age 45.
Cigarette smoking is the leading cause of lung cancer. The more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. There is no evidence that smoking low-tar cigarettes lowers the risk.
Lung cancer can also affect people who have never smoked.
Secondhand smoke (breathing the smoke of others) increases your risk of lung cancer.
The following may also increase your risk of lung cancer:
Early lung cancer may not cause any symptoms.
Symptoms depend on the type of cancer you have, but may include:
Other symptoms that may also occur with lung cancer, often in the late stages:
These symptoms can also be due to other, less serious conditions, so it is important to talk to your health care provider.
Lung cancer is often found when an x-ray or CT scan is done for another reason.
If lung cancer is suspected, the doctor will perform a physical exam and ask about your medical history. You will be asked if you smoke. If so, you'll be asked how much you smoke and for how long you have smoked. You will also be asked about other things that may have put you at risk of lung cancer, such as exposure to certain chemicals.
When listening to the chest with a stethoscope, the doctor may hear fluid around the lungs. This may suggest cancer.
Tests that may be done to diagnose lung cancer or see if it has spread include:
In most cases, a piece of tissue is removed from your lungs for examination under a microscope. This is called a biopsy. There are several ways to do this:
If the biopsy shows cancer, more imaging tests are done to find out the stage of the cancer. Stage means how big the tumor is and how far it has spread. Staging helps guide treatment and follow-up and gives you an idea of what to expect.
Treatment for lung cancer depends on the type of cancer, how advanced it is, and how healthy you are:
The above treatments may be done alone or in combination. Your doctor can tell you more about the specific treatment you will receive depending on the specific type of lung cancer and what stage it is.
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
How well you do depends mostly on how much the lung cancer has spread.
Call your provider if you have symptoms of lung cancer, particularly if you smoke.
Horn L, Eisenberg R, Gius D, et al. Cancer of the lung. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 72.
Ettinger DS, Wood DE, Akerley W, et al. NCCN clinical practice guidelines in oncology: non-small cell lung cancer, Version 6.2015. J Natl Compr Canc Netw. 2015;(5):515-524. PMID: 25964637
Ettinger DS, Wood DE, Akerley W, et al. NCCN clinical practice guidelines in oncology: non-small cell lung cancer, version 1.2015. J Natl Compr Canc Netw. 2014;12(12):1738-1761. PMID: 25505215
National Cancer Institute. Non-small cell lung cancer treatment (PDQ)-health professional version. Updated July 7, 2016.
National Cancer Institute. Small cell lung cancer treatment (PDQ)-health professional version. Updated July 7, 2016.
Silvestri GA, Pastis NJ, Tanner NT, Jett JR. Clinical aspects of lung cancer. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 53.
Last reviewed on: 8/1/2015
Reviewed by: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Internal review and update on 09/01/2016 by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.