Liver cirrhosis; Chronic liver disease; End-stage liver disease; Liver failure - cirrhosis; Ascites - cirrhosis
Cirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.
Cirrhosis is the end result of chronic liver damage caused by chronic (long-term) liver disease. Common causes of chronic liver disease in the United States are:
Less common causes of cirrhosis include:
There may be no symptoms, or symptoms may come on slowly, depending on how well the liver is working. Often, it is discovered by chance when an x-ray is done for another reason.
Early symptoms include:
As liver function worsens, symptoms may include:
Your health care provider will do a physical exam to look for:
You may have the following tests to measure liver function:
Other tests to check for liver damage include:
You might need a liver biopsy to confirm the diagnosis.
Some things you can do to help take care of your liver disease are:
MEDICINES FROM YOUR DOCTOR
When cirrhosis progresses to end-stage liver disease, a liver transplant may be needed.
You can often ease the stress of illness by joining a liver disease support group whose members share common experiences and problems.
Cirrhosis is caused by scarring of the liver. In most cases, the liver cannot heal or return to normal function once damage is severe. Cirrhosis can lead to serious complications.
Complications may include:
Call your provider if you develop symptoms of cirrhosis.
Get emergency medical help right away if you have:
Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the AmericanGastroenterological Association. Hepatology. 2012;55(6):2005-2023. PMID: 22488764
Garcia-Tsao G, Lim JK; Members of Veterans Affairs Hepatitis C Resource Center Program. Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program. Am J Gastroenterol. 2009;104(7):1802-1829. PMID: 19455106
Garcia-Tsao G. Cirrhosis and its sequelae. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 153.
Kamath PS, Shah VH. Overview of cirrhosis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 74.
Mehta G, Rothstein KD. Health maintenance issues in cirrhosis. Med Clin North Am. 2009;93(4):901-915. PMID: 19577121
O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology. 2010;105(1):14-32. PMID: 19904248
Last reviewed on: 8/14/2015
Reviewed by: Subodh K. Lal, MD, gastroenterologist at Gastrointestinal Specialists of Georgia, Austell, GA. Review provided by VeriMed Healthcare Network. Internal review and update on 09/01/2016 by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.