Bimekizumab in Plaque Psoriasis
The purpose of this research study is to evaluate the effectiveness and safety of bimekizumab
in individuals with moderate-to-severe psoriasis who have failed similar therapies.
Bimekizumab improves psoriasis by suppressing a type of substance found in bodies called...
Age: 18 years - 66+
Gender: All
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and
gut microbiome in order to understand the role of this pollutant on the risk of developing
inflammatory bowel disease (IBD) as well as other diseases. With this information...
Age: 18 years - 66+
Gender: All
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and
bleeding from the lining of the rectum and colon (large intestine). This study will assess
how safe and effective Upadacitinib is in treating pediatric participants with UC....
Age: 2 - 17 years
Gender: All
The Ambient Light Multiple Myeloma Study
The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. T...
Age: 21 years - 66+
Gender: All
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
This study is a platform protocol designed to be flexible so that it is suitable for a wide
range of settings within health care systems and in community settings where it can be
integrated into COVID-19 programs and subsequent treatment plans. This protocol is a
...
Age: 18 years - 66+
Gender: All
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).
Age: 18 years - 66+
Gender: All
Renal Allograft Fibrosis Study
Despite the reduction in acute rejection episodes in renal transplant patients due to modern
immunosuppression, proportionate improvements in long-term allograft survival have not been
achieved. Virtually any disease or injury affecting renal allografts can culminat...
Age: 18 years - 66+
Gender: All
Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis
This study will compare the effects of AXA1125, an orally active mixture of amino acids,
compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis
in subjects with non alcoholic steatohepatitis (NASH). as well as the safety and tol...
Age: 18 years - 66+
Gender: All
Study to Evaluate Safety, Tolerability and Efficacy of Oral E-B-FAHF-2 in Mild-to-Moderate Crohn's Disease
Crohn's disease (CD) is the major form of inflammatory bowel disease (IBD) affecting adults.
It is a life-long disease characterized by chronic and relapsing inflammation of the
gastrointestinal tract. CD has multiple clinical phenotypes and disease severities that
...
Age: 18 - 30 years
Gender: All
Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease
The MELODY Trial: Modulating Early Life Microbiome through Dietary Intervention in Crohn's
Disease, will test whether a non-invasive dietary intervention during pregnancy can improve
the gut microbiota composition in both pregnant Crohn's disease patients and their ...
Age: 18 years - 66+
Gender: Female
A Double-Masked, Placebo-Controlled, Randomized, Phase II Clinical Trial To Assess The Efficacy Of SCH1 In The Treatment Of Acute Infectious Conjunctivitis
Acute infectious conjunctivitis is a leading cause of ocular morbidity, epidemic eye infection, lost productivity, patient discomfort and in some cases permanent visual compromise. The infectious agent is frequently viral in origin and frequently bacterial in origin wit...
Age: 18 - 90 years
Gender: All
Light and the Effect on Metabolic Syndrome and Alzheimer's Disease
This study's main hypothesis is that a delivering a tailored lighting intervention (TLI) will
provide a successful means for promoting circadian entrainment and treating metabolic disease
and inflammation in patients with mild cognitive impairment (MCI) and Alzheime...
Age: 55 years - 66+
Gender: All
An open-label pilot study to investigate the efficacy of apremilast in the treatment of central centrifugal cicatricial alopecia (CCCA)
"The purpose of this study is to see if the use of apremilast has an effect on the symptoms and progression of central centrifugal cicatricial alopecia (CCCA). Apremilast is an oral PDE4 inhibitor that has anti-inflammatory properties. It inhibits several substances inv...
Age: 18 years - 66+
Gender: Female
Autologous Stem Cell Transplant for Crohn's Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant
complications and discomfort in the stomach and intestines. Crohn's disease is a
debilitating, incurable disease of immune cells; it affects almost 1 million people in the
United Sta...
Age: 18 years - 66+
Gender: All
Comparing Hypothermic Temperatures During Hemiarch Surgery
Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic
surgeries to be performed safely. Hypothermic circulatory arrest provides protection to
cerebral and visceral organs, but may result in longer cardiopulmonary bypass times dur...
Age: 18 years - 66+
Gender: All
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic diseases.
Patients included in the registry may include those with: pancreatic cancer, precancerous
lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the
...
Age: 18 years - 66+
Gender: All