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Full/Part Time: Full Time
Department: 824 - Oncological Sciences
Requisition Number: PD14-1648952
Study MDSC lineage commitment throguh the use of KO mice defective in M2 or M1 functional phenotypes and their effects on GVHD and development of NKG2D+ memory T cells.
The effects of PIR-B ligands on the baility of MDSC to inhibit GVHD and the underlying signaling regulation in an irradiated host.
Study the mechanism and effects of MDSC and NKG2D+ memeory T cells mediated differential regulation of GVHD vs. GVL through PIR-B/NKG2D engagement in vivo.
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