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Full/Part Time: Full Time
Location/Affiliates: Mount Sinai Medical Center (Manhattan)
Department: 031 - Hematology/Oncology
Requisition Number: PD13-1607518
The Mount Sinai School of Medicine has a Post-Doctoral Fellow opening immediately available in the laboratory of Dr. Joshua Brody - Director, Lymphoma Immunotherapy Program. This individual will perform a wide variety of moderately complex laboratory tasks/experiments, and maintain lab equipment and inventory levels of supplies. Responsibilities of this position involve designing protocols and carrying out experiments, interpreting results, and preparing figures to convey analyses. Experimental duties will include but are not limited to performing cellular and molecular immunology techniques such as Flow Cytometry, ELISA, Luminex, and studies with animals as well as primary patient specimens. The lab will provide the chance to learn novel aspects of basic and tumor immunology, multi-parametric flow cytometry and phospho-flow signaling studies, animal techniques including bone marrow transplantation, anti-tumor vaccinations, and a large variety of functional assessments of anti-tumor T cell induction. Side projects include bioinformatic-based collaborations with colleagues tracking T-cell responses using high-throughput sequencing of the entire TCRbV repertoire and studies of small-molecule inhibitors of lymphocyte signal transduction, e.g. PI3K, mTOR, btk. Our lab has the rare opportunity to both perform correlative studies on primary patient tumor samples from early phase clinical trials and to continually develop advancements in those trials based on what is learned. The core mission is the translation of basic science in tumor immunology into novel and rapidly accruing clinical trials:
Brody J, et al., In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol. 2010 Oct 1;28(28):4324-32.
Brody J, et al., Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors. Blood. 2009 Jan 1;113(1):85-94.
Brody J, et al., Immunotransplant for mantle cell lymphoma: Phase I/II study preliminary results. J Clin Oncol 29: 2011 (suppl; abstr 2509)
Brody J, et al., Active and passive immunotherapy for lymphoma: proving principles and improving results. J Clin Oncol. 2011 May 10;29(14):1864-75.
1. *Conducts a variety of research experiments using advanced research techniques.
2. *Coordinates project activities to meet deadlines.
3. *Collaborates with the Principal Investigator in the development of new experiments and research techniques.
4. *Assists in the implementation of standardized protocols for experiments and training purposes.
5. *Assists the Principal Investigator with publications by extracting and compiling data; reviewing and editing articles for publication.
6. Mentors and trains less experienced research staff and graduate students.
7. Ensures compliance with safety and regulatory requirements.
8. Performs other related duties
*-indicates duty is "essential" as defined by the Americans with Disabilities Act (AD
Bachelor's Degree in sciences or related field or equivalent experience. Ph.D. Degree in sciences or related field preferred.
3 years in a research environment
Microsoft Word, Excel, Powerpoint - Intermediate
Flow Cytometry Analysis Software - Intermediate
Excellent organizational, problem solving and analytical skills
Excellent verbal, written and interpersonal communication skills
Knowledge of standard research concepts
Mount Sinai Medical Center is an equal opportunity/affirmative action employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds. Mount Sinai Medical Center--An EEO/AA-D/V Employer.