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Full/Part Time: Full Time
Location/Affiliates: Mount Sinai Medical Center (Manhattan)
Department: 031 - Hematology/Oncology
Requisition Number: PD13-1600588
NIH-funded Postdoctoral Fellow positions are available to investigate molecular mechanisms of hematopoietic stem and progenitor cell fate specification using mouse and human primary cell and ES cell models and animals. One focus of the lab is to study the Wnt signaling and other pathways in embryonic hematopoiesis and erythropoiesis. A second focus is on definitive hematopoietic and erythroid progenitor development (mouse fetal liver or bone marrow, human progenitors from peripheral blood or bone marrow). We are developing a high throughput screen for regulators of erythroid progenitors as well as later stages of maturation, including enucleation, and are targeting specific metabolic/hormonal pathways for detailed analysis. EXPERIMENTAL APPROACHES include classical cell and molecular biology techniques, small interfering RNA viral technologies, RNA profiling and RNAseq, novel computational methods developed by a collaborator, chromatin immunoprecipitation (ChIP), and genetic manipulation of mice. Finally, we are beginning to apply what we have learned from our studies on embryonic red blood cells to the development of adult red blood cells in human patients with hematological diseases. Outstanding facilities. Salary commensurate with experience.
FOR ADDITIONAL INFORMATION, PLEASE SEE: http://icahn.mssm.edu/research/labs/baron-laboratory/about-us, http://icahn.mssm.edu/profiles/margaret-h-baron.
The ideal candidate should be highly motivated, have an MD and/or PhD degree, and a strong background in molecular biology, cell biology, hematopoiesis, and/or mouse genetics and publications in internationally recognized journals. Applicants should be fluent in English and be available for an interview. Experience with mammalian cell culture, FACS analysis, fluorescence/confocal microscopy, and/or analysis of transgenic/knockout mice strongly preferred.
Mount Sinai Medical Center is an equal opportunity/affirmative action employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds. Mount Sinai Medical Center--An EEO/AA-D/V Employer.