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Laboratory Operations Manager

Full/Part Time: Full Time
Location/Affiliates: The Mount Sinai Hospital
Department: 856 - Pharmacology/Biologi
Requisition Number: 14-1623306

Job Description:

The role will require the design and synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology and drug discovery research efforts. In addition, the candidate will be responsible for the day-to-day management of the laboratory as well as mentorship of postdoctoral fellows. Preparation, purification and characterization of compounds; documentation of all experiments in notebooks including written, publication quality, experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS for example. All aspects of laboratory management including inventory and ordering of supplies, commercial chemical storage and inventory, chemical and biological database management, new compound management, inventory and storage. All aspects of local laboratory safety in collaboration with institutional safety staff and requirements.

Job Qualifications:

Ph.D. or MS, with 8-10 yrs pharmaceutical or biotech medicinal chemistry, small molecule, drug discovery experience.

Specific knowledge in heterocyclic and organometallic chemistry; demonstrated experience in the synthesis, purification, and analysis of complex organic molecules; experience with new method development, rapid analog and library synthesis techniques; multi-step synthetic processes and larger, multi-gram reaction scale-up. Microwave assisted synthesis. Excellent reaction trouble shooting skills. Characterization of new molecules by NMR and MS. Excellent English written and oral presentation skills; Experience with intellectual property chemical patents and writing patent applications. Experience with the safe handling of reactive and air-sensitive materials. Previous experience with mentoring and supervising of laboratory personnel. Ability to maintain and troubleshoot laboratory instruments.

Essential skills include Organic synthesis in the area of heterocyclic chemistry and organic synthesis; purification and analysis of reaction products; methodology development; design of novel analogs; design and testing of synthetic routes to desired analogs. Laboratory management skills.

Mount Sinai Medical Center is an equal opportunity/affirmative action employer. We recognize the power and importance of a diverse employee population and strongly encourage applicants with various experiences and backgrounds. Mount Sinai Medical Center--An EEO/AA-D/V Employer.

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