"Leading Genetics Study Method May Need Reconsideration, Significant Distortions Discovered"
Many conclusions drawn from a common approach to the study of human genetics could be distorted because of a previously overlooked phenomenon, according to researchers at the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai and collaborators from Massachusetts General Hospital and the Broad Institute. Their conclusions and a unique method they developed to help correct for this distortion were recently published in Nature Genetics. "Mendelian randomization has significant implications for drug discovery and validation," said Ron Do, PhD, assistant professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. "It can be used to determine whether biomarkers are causal for disease, which can determine what types of drug therapeutics may be worth exploring in clinical trials, and can potentially predict accurate dosing for drug effectiveness."
- Ron Do, PhD, Assistant Professor, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai