Grape Compound Protects Against Depression, Mouse Research Reveals - Elizabeth Doughman

Natural compounds found in grapes could ward off stress-induced depression, according to new research found in Nature Communications. Scientists at the Icahn School of Medicine at Mount Sinai conducted an extensive analysis of two new grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc). The research team found that a bioactive dietary polyphenol product that included a select Concord grape juice, a select grape seed extract, and trans-resveratrol effectively treated stress-induced depression in mice. "We hope to translate our findings into a clinical setting, where we believe the treatment could effectively decrease difficult to treat symptoms associated with depression by targeting mechanisms of inflammation in a subset of patients who are refractive to current treatment options," said Giulio Maria Pasinetti, PhD, MD, Saunders professor of neurology, and program director for the center of molecular integrative neuroresilience at the Icahn School of Medicine at Mount Sinai.

• Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai
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