Working Memory Is Positively Associated With Higher Physical Endurance and Better Cognitive Function, Mount Sinai Researchers Find
Suboptimal cardiovascular health, binge drinking, and smoking are associated with less cohesive brain network
Mount Sinai researchers have found a positive relationship between the brain network associated with working memory—the ability to store and process information relevant to the task at hand—and healthy traits such as higher physical endurance and better cognitive function.
These traits were associated with greater cohesiveness of the working memory brain network while traits indicating suboptimal cardiovascular and metabolic health, and suboptimal health habits including binge drinking and regular smoking, were associated with less cohesive working memory networks.
This is the first study to establish the link between working memory and physical health and lifestyle choices.
The results of the study will be published online in Molecular Psychiatry on Tuesday, December 5, at 4 am EST.
The research team took brain scans of 823 participants in the Human Connectome Project (HCP), a large brain imaging study funded by the National Institutes of Health, while they performed a task involving working memory, and extracted measures of brain activity and connectivity to create a brain map of working memory. The team then used a statistical method called sparse canonical correlation to discover the relationships between the working memory brain map and 116 measures of cognitive ability, physical and mental health, personality, and lifestyle choices. They found that cohesiveness in the working memory brain map was positively associated with higher physical endurance and better cognitive function. Physical traits such as high body mass index, and suboptimal lifestyle choices including binge alcohol drinking and regular smoking, had the opposite association.
“Working memory accounts for individual differences in personal, educational, and professional attainment,” said Sophia Frangou, MD, PhD, Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai. “Working memory is also one of the brain functions that is severely affected by physical and mental illnesses. Our study identified factors that can either support or undermine the working memory brain network. Our findings can empower people to make informed choices about how best to promote and preserve brain health.”
This study was supported by grants from the National Institutes of Health (R01 MH104284-01A1) and European Unit FP7 program (IMAGEMEND 602450; IMAging GEnetics for MENtal Disorders) projects, the Swiss National Science Foundation, the National Institute for HealthResearch (NIHR; Biomedical Research Centre at South London and Maudsley NHSFoundation Trust and King’s College London) and the Bundesministerium für Bildung und Forschung (eMED SysAlc01ZX1311A).HCP data are disseminated by the Laboratory of Neuro Imaging at the University of Southern California.
About the Mount Sinai Health System
The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.
The System includes approximately 7,100 primary and specialty care physicians; 12 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. Physicians are affiliated with the renowned Icahn School of Medicine at Mount Sinai, which is ranked among the highest in the nation in National Institutes of Health funding per investigator. The Mount Sinai Hospital is in the "Honor Roll" of best hospitals in America, ranked No. 15 nationally in the 2016-2017 "Best Hospitals" issue of U.S. News & World Report. The Mount Sinai Hospital is also ranked as one of the nation's top 20 hospitals in Geriatrics, Gastroenterology/GI Surgery, Cardiology/Heart Surgery, Diabetes/Endocrinology, Nephrology, Neurology/Neurosurgery, and Ear, Nose & Throat, and is in the top 50 in four other specialties. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 10 nationally for Ophthalmology, while Mount Sinai Beth Israel, Mount Sinai St. Luke's, and Mount Sinai West are ranked regionally. Mount Sinai's Kravis Children's Hospital is ranked in seven out of ten pediatric specialties by U.S. News & World Report in "Best Children's Hospitals."