"Study Elucidates How Antidepressants May Lessen Neuropathic Pain"
In a study published in the Proceedings of the National Academy of Sciences in August, researchers at the Icahn School of Medicine at Mount Sinai and their colleagues discovered that the tricyclic antidepressant (TCA) desipramine may alleviate neuropathic pain by modulating specific cellular signaling events in the nucleus accumbens. The team also found that one protein in particular, RGS9-2, plays a key role in mediating the therapeutic efficacy of TCAs. Now, the study is being featured in the Journal of the American Medical Association's "Lab Reports" feature.
- Venetia Zachariou, PhD, Associate Professor, Neuroscience, Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai
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Mount Sinai Researchers Identify Brain Protein That Promotes Maintenance of Chronic Pain
Oct 16, 2019 View All Press Releases