GNS Healthcare, Dana-Farber and Mount Sinai Collaborate to Build Computer Model of Multiple Myeloma
Collaborators will unravel underlying biology of Multiple Myeloma and advance discovery of new treatments.
GNS Healthcare, Inc. (GNS), the leading healthcare data analytics company focused on enabling personalized medicine to improve human health, today announced that it has entered into a collaboration with Dana-Farber Cancer Institute (Dana-Farber) and Mount Sinai School of Medicine (Mount Sinai) to create a data-driven computer model of multiple myeloma, the second most common blood cancer in the U.S. that constitutes approximately one percent of all cancers. Created using GNS’s supercomputer-driven REFS™ (Reverse Engineering and Forward Simulation) platform, the models will be used to help researchers discover novel therapies for the disease and to help determine the best existing treatments for patients.
"We have made encouraging progress at Dana-Farber Cancer Institute in using gene profiling, proteomic and signaling studies in tumor cell samples treated with existing and novel medicines to get a better understanding of myeloma pathogenesis and to develop novel targeted therapies," said Dr. Ken Anderson, Director, Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics at Dana-Farber and Kraft Family Professor of Medicine at Dana-Farber and Harvard Medical School.
"Because of this progress, our team is excited about deploying a powerful, supercomputer driven approach using our multi-layered genomic data to develop computer models to directly define the integrated underlying circuitry of myeloma. We look forward to using these models to identify, create, and implement better treatments for individual multiple myeloma patients," said Dr. Nikhil Munshi, Associate Director, Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics at Dana-Farber and Associate Professor of Medicine, Harvard Medical School.
"GNS will apply its Big Data analytics platform to create a disease-specific computer model that will yield a powerful new resource to the multiple myeloma research and clinical community—with the ultimate aim of better outcomes for patients," said GNS CEO and co-founder Colin Hill. "This collaboration with Dana-Farber and Mount Sinai will create models that will help transform the tremendous amount of data coming from new technologies, such as next-generation sequencing, into predictive computer models of disease progression and treatment response for scientists and clinicians. This project is one of many examples of our work in challenging, complex and, sometimes rare, diseases."
In this collaboration, GNS will employ the REFS™ platform to reverse engineer network models from next-generation genetic sequencing, proteomic, outcomes and other clinical data. Results from millions of in silico simulations of the REFS™ models will provide new insights into the fundamental mechanisms of multiple myeloma, enabling the identification of novel intervention points in the disease for specific groups of patients and the development of more effective medicines.
"Prior published work has shown us that approaches like the REFS™ platform can develop integrated network models of disease that can be used to uncover novel drivers of disease," said Dr. Eric Schadt, Director of the Institute for Genomics and Multiscale Biology, Chair of the Department of Genetics and Genomics Sciences and the Jean C. and James W. Crystal Professor of Genomics at Mount Sinai. "With the wealth of detailed biological data available in this project, we look forward to a close collaboration with GNS to build a predictive model to elucidate novel insights into this complex disease."
About Multiple Myeloma
Multiple myeloma is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells. Most cases of myeloma also feature the production of a paraprotein—an abnormal antibody which can cause kidney problems. Bone lesions and hypercalcemia (high calcium levels) are also often encountered. Myeloma is diagnosed with blood tests (serum protein electrophoresis, serum free kappa/lambda light chain assay), bone marrow examination, urine protein electrophoresis and X-rays of commonly involved bones. Myeloma is generally thought to be treatable but incurable. Remissions may be induced with steroids, chemotherapy, proteasome inhibitors (e.g. bortezomib), immunomodulatory drugs (IMiDs) such as thalidomide or lenalidomide and stem cell transplants. Radiation therapy is sometimes used to reduce pain from bone lesions. Myeloma develops in 1-4 per 100,000 people per year. It is more common in men, and for unknown reasons is twice as common in African-Americans as it is in white Americans. With conventional treatment, median survival is 3-4 years, which may be extended to 5-7 years or longer with advanced treatments. Multiple myeloma is the second most common hematological malignancy in the U.S. (after non-Hodgkin lymphoma) and constitutes 1 percent of all cancers.
REFS™ (Reverse Engineering and Forward Simulation) is GNS Healthcare's scalable, supercomputer-enabled framework for discovering new knowledge directly from data. REFS™ automates the discovery and extraction of causal network models from observational data and uses high-throughput simulations to generate new knowledge.
About GNS Healthcare
GNS Healthcare is a 'Big Data' analytics company that has developed a scalable approach for the discovery of what works in healthcare, and for whom. GNS analytics solutions are being applied across the healthcare industry: from pharmaceutical and biotechnology companies, health plans and hospitals, to integrated delivery systems, Pharmacy Benefits Managers (PBMs) and Accountable Care Organizations (ACOs). GNS Healthcare discovers the knowledge needed to match patients with treatments that work. www.gnshealthcare.com
About Dana-Farber Cancer Institute
Dana-Farber Cancer Institute (www.dana-farber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult care with Brigham and Women’s Hospital as Dana-Farber/Brigham and Women’s Cancer Center, and it provides pediatric care with Boston Children’s Hospital as Dana-Farber/Children’s Hospital Cancer Center. Dana-Farber is the top-ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Twitter: @dana-farber or Facebook: facebook.com/danafarbercancerinstitute.
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.
The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.
For more information, visit http://www.mountsinai.org/.
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