"CD4 Receptors and the Immune Response to HIV"
Researchers recently found that Human Immunodeficiency Virus-1 (HIV) virions move similarly to influenza within cells, and that CD4-HIV interactions may mediate type I interferon (IFN) production. The study, conducted by Meagan O’Brien, MD, a professor of infectious diseases at the Icahn School of Medicine at Mount Sinai, and colleagues, and was published in PLOS Pathogens. They hypothesized, “that HIV envelope protein interactions with cell surface CD4 determine the intracellular trafficking of HIV and the resultant signaling in pDC, based on the spatiotemporal model of TLR signaling.” Learn more.
Mount Sinai Studies Inform Path to Zika Treatment
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