HealthDay - "Scientists Inch Closer to Genetic Blueprint of Diseases"
A study appearing online in Science provides a blueprint not only of genes that are involved in different disorders, but also of the "switches" that control those genes and how these two elements interact. The authors of an accompanying editorial agreed that the finding could shed light on disease mechanisms. "Many of these variations in DNA that are associated with disease are not directly affecting protein sequences," explained Dr. Eric Schadt, co-author of the accompanying perspective and chairman of genetics and genomic sciences at Mount Sinai School of Medicine. "They are affecting regions in the DNA that regulate whether genes should be expressed or not, and at what level. They're playing more of a regulatory role versus a protein-function role. We are able to see that loud and clear in [this] data." Learn more