Sobie Laboratory

Gold Divider 4Col

Recognition and Publications

Trafford AW, Lederer WJ, Sobie EA. Keeping the beat: life without SERCA--is it possible? J Mol Cell Cardiol. 2009 Aug;47(2):171-3.

Sobie EA, Ramay HR. Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model. J Physiol. 2009 Mar 15;587(Pt 6):1293-9.

Sobie EA. Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J. 2009 Feb 18;96(4):1264-74.

Bridge JH, Torres NS, Sobie EA. New insights into the structure and function of couplons. J Physiol. 2008 Aug 15;586(16):3735.

Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GC. Moment closure for local control models of calcium-induced calcium release in cardiac myocytes. Biophys J. 2008 Aug;95(4):1689-703.

Lipsky R, Potts EM, Tarzami ST, Puckerin AA, Stocks J, Schecter AD, Sobie EA, Akar FG, Diverse-Pierluissi MA. {beta}-Adrenergic Receptor Activation Induces Internalization of Cardiac Cav1.2 Channel Complexes through a {beta}-Arrestin 1-mediated Pathway. J Biol Chem. 2008 Jun 20;283(25):17221-6.

Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2565-75.

Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29;319(5867):1189-90.

Sobie EA, Cannell MB, Bridge JH. Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes. Biophys J. 2008 Apr 1;94(7):L54-6.

Sobie EA, Kao JP, Lederer WJ. Novel approach to real-time flash photolysis and confocal Ca2+ imaging. Pflugers Arch: European Journal of Physiology 2007 Jul;454(4):663-73.

Ni J, Auston DA, Freilich DA, Muralidharan S, Sobie EA, Kao JP. Photochemical gating of intracellular Ca2+ release channels. J Am Chem Soc. 2007 May 2;129(17):5316-7.

Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GD. A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes. Biophys J. 2007 Apr 1;92(7):2311-28.

Collis LP, Meyers MB, Zhang J, Phoon CK, Sobie EA, Coetzee WA, Fishman GI. Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling. FASEB J. 2007 Feb;21(2):475-87.

Sobie EA, Song LS, Lederer WJ. Restitution of Ca2+ release and vulnerability to arrhythmias. J Cardiovasc Electrophysiol. 2006; 17 Suppl 1: S64-S70.

Sobie EA, Guatimosim S, Gomez-Viquez L, Song LS, Hartmann H, Saleet JM, et al. The Ca2+ leak paradox and rogue ryanodine receptors: SR Ca2+ efflux theory and practice. Prog Biophys Mol Biol. 2006; 90: 172-185.

Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A. 2006; 103: 4305-4310.

Knot HJ, Laher I, Sobie EA, Guatimosim S, Gomez-Viquez L, Hartmann H, et al. Twenty years of calcium imaging: cell physiology to dye for. Mol Interv. 2005; 5: 112-127.

Sobie EA, Song LS, Lederer WJ. Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol. 2005; 565: 441-447.

Song LS, Guatimosim S, Gomez-Viquez L, Sobie EA, Ziman A, Hartmann H, et al. Calcium biology of the transverse tubules in heart. Ann N Y Acad Sci. 2005; 1047: 99-111.

Lederer WJ, Guatimosim S, Song LS, Sobie EA, Hartmann H, Lukyanenko V. Ca2+ sparks in heart muscle. J Muscle Res Cell Motil. 2004; 25: 602-603.

Sobie EA, Jafri MS, Lederer WJ. Computer models of cardiac Ca2+ release and Ca2+ sparks. Lecture Notes in Physics. 2003; 623: 97-114.

Sobie EA, Guatimosim S, Song LS, Lederer WJ. The challenge of molecular medicine: complexity versus Occam's razor. J Clin Invest. 2003; 111: 801-803.

Zhang H, Noble D, Cannell M, Orchard CH, Lancaster M, Jones SA, et al. Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells. International Journal of Bifurcation and Chaos. 2003; 13: 3535-3560.

Guatimosim S, Dilly K, Santana LF, Jafri MS, Sobie EA, Lederer WJ. Local Ca2+ signaling and EC coupling in heart: Ca2+ sparks and the regulation of the [Ca2+]i transient. J Mol Cell Cardiol. 2002; 34: 941-950.

Sobie EA, Dilly KW, Dos Santos CJ, Lederer WJ, Jafri MS. Termination of cardiac Ca2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J. 2002; 83: 59-78.

Guatimosim S, Sobie EA, Dos Santos CJ, Martin LA, Lederer WJ. Molecular identification of a TTX-sensitive Ca(2+) current. Am J Physiol Cell Physiol. 2001; 280: C1327-C1339.

Cheng DK, Tung L, Sobie EA. Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells. Am J Physiol. 1999; 277: H351-H362.

Susil RC, Sobie EA, Tung L. Separation between virtual sources modifies the response of cardiac tissue to field stimulation. J Cardiovasc Electrophysiol. 1999; 10: 715-727.

Riemer TL, Sobie EA, Tung L. Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models. Am J Physiol. 1998; 275: 431-42.

Sobie EA, Tung L. Postshock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms. J Cardiovasc Electrophysiol. 1998; 9: 743-756.

Sobie EA, Susil RC, Tung L. A generalized activating function for predicting virtual electrodes in cardiac tissue. Biophys J. 1997; 73: 1410-1423.

Fishler MG, Sobie EA, Tung L, Thakor NV. Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli - the importance of the induced spatial excitatory response. J Cardiovasc Electrophysiol. 1996; 7: 1183-1196.

Fishler MG, Sobie EA, Thakor NV, Tung L. Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli - a model study. Biophys J. 1996; 70: 1347-1362.

Fishler MG, Sobie EA, Tung L, Thakor NV. Cardiac responses to premature monophasic and biphasic field stimuli: results from cell and tissue modeling studies. J Electrocardiol. 1995; 28: 174-179.

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