Ben MacArthur, Ph.D.
Postdoctoral Fellow
Department of Pharmacology and Systems Therapeutics
E-mail: ben.macarthur@mssm.edu

Training and Education

Postdoctoral Fellow (2003-2008) Bone and Joint Research Group, University of Southampton

Ph.D.(2003) Applied Mathematics, Mathematical Biology, University of Southampton, School of Mathematics, U.K.

M.Math (1999) Pure and Applied Mathematics, University of Southampton, School of Mathematics, U.K.

Research Interests

The mathematics of complex biological systems: In particular, I am interested in using mathematical techniques to understand the ways in which internal regulatory architecture relates to cell behavior; and the ways in which individual cell behavior relates to collective dynamics in cellular populations. I am also interested in using biological problems as a stimulus to develop new mathematical tools for application to non-biological problems.

Publications

Macarthur BD, Ma'ayan A, Lemischka IR. Toward stem cell systems biology: From molecules to networks and landscapes. Cold Spring Harb Symp Quant Biol. 2009 Mar 27.

Macarthur BD, Tare RS, Murawski K, Oreffo RO. Identification of candidate regulators of multipotency in human skeletal progenitor cells. Biochem Biophys Res Commun. 2008 Sep 25.

MacArthur BD, Please CP, Oreffo RO. Stochasticity and the molecular mechanisms of induced pluripotency. PLoS ONE. 2008 Aug 28;3(8):e3086.

Xiao Y, MacArthur BD, Wang H, Xiong M and Wang W. Network quotients: Structural skeletons of complex systems. Phys. Rev. E 78, 046102 (2008).

MacArthur BD, Sanchez RJ and Anderson JW.  Symmetry in complex networks. Discrete Applied Mathematics. 2008 10.1016/j.dam.2008.04.008.

MacArthur BD, Tare RS, Please CP, Prescott P, Oreffo RO. A non-invasive method for in situ quantification of subpopulation behaviour in mixed cell culture. J R Soc Interface. 2006 Feb 22;3(6):63-9.

MacArthur BD, Oreffo RO. Bridging the gap. Nature. 2005 Jan 6;433(7021):19.

Lewis MC, Macarthur BD, Malda J, Pettet G, Please CP. Heterogeneous proliferation within engineered cartilaginous tissue: the role of oxygen tension. Biotechnol Bioeng. 2005 Sep 5;91(5):607-15.

MacArthur BD, Please CP, Pettet GJ. A mathematical model of dynamic glioma-host interactions: receptor-mediated invasion and local proteolysis. Math Med Biol. 2005 Sep;22(3):247-64.

MacArthur BD, Please CP. Residual stress generation and necrosis formation in multi-cell tumour spheroids. J Math Biol. 2004 Dec;49(6):537-52.

MacArthur BD, Please CP, Taylor M, Oreffo RO. Mathematical modelling of skeletal repair. Biochem Biophys Res Commun. 2004 Jan 23;313(4):825-33.

MacArthur BD, Tare RS, Please CP, Prescott P and Oreffo RO. Variations in human osteoprogenitor adhesion patterns reveal a method for in situ investigation of sub-population behaviour in heterogeneous cell populations: Implications for tissue regeneration, Journal of Bone and Mineral Research 20 (7) 2005, p1302.

MacArthur BD, Tare RS, Please CP, Prescott P and Oreffo RO. In Situ quantification of subpopulation behavior in heterogeneous cell populations: Implications for tissue regeneration, European Cells and Materials 10 (2) 2005, p31.