Projects

1. The genetic and cellular mechanisms underlying the pathophysiology of diabetic cardiomyopathy
   Objective: to investigate the consequences of diabetes on cardiac function and the role of insulin resistance and cardiometabolism dysregulation in contractile failure
2. Proteomic and Genomic Profiling of Diabetes-induced Cardiac Dysfunction
   Objective: to investigate the global changes in gene and protein expression profiles accompanying diabetic cardiomyopathy in human and animal models. Functional significance of potential new candidates and pathways are examined.
3. Identification and Functional Characterization of SERCA2a-target Genes
   Objective: to identify and characterize new target genes and proteins whose expression is altered by SERCA2a in heart failure.
4. Electrical Remodeling and Cardiac Hypertrophy
   Objective: to investigating the molecular and ionic basis of action potential prolongation in cardiac hypertrophy and failure using gene transfer of various K channels and chaperones.

Recent Grants

5/01/04-4/30/09-PI
NIH/NHLBI K01 HL076659
Electrical Remodeling and Cardiac Hypertrophy and Signaling
$90,000/year

4/07-3/11, Co-PI
NIH/NHLBI R01 HL 07873
Genetic Editing of Calcium Cycling in Diabetic Cardiomyopathy
$250,000/year