These tests help in the prediction of a person's response to treatment with various drugs and in the choice of the best treatment/dosing regimen

Warfarin

• Objective: To guide Warfarin dosing and to reduce side-effect(s)
• Description: Detect genetic variants in the CYP450 genes (CYP2C9*2 and CYP2C9*3) and VKOR genes (VKORC1-1639G>A) that affect warfarin metabolism and sensitivity
• Performing Lab: Molecular Pathology
  Direct inquiries to Dr. David Y. Zhang (212-659-8173)
• Specimen requirements: One (1) lavender top (EDTA) tube (4ml) from peripheral blood

UGT1A1

• Objective: To guide irinotecan dosing and to reduce drug toxicity for patients undergoing treatment for colorectal cancer
• Description: Detect genetic variants in the UDP glucuronosyltransferase 1A1 (UGT1A1) gene (*1 (TA6) and *28 (TA7) alleles) that affect irinotecan metabolism by the UGT1A1 enzyme
• Performing Lab: Molecular Pathology
  Direct inquiries to Dr. David Y. Zhang (212-659-8173)
• Specimen requirements: One (1) lavender top (EDTA) tube (4ml) from peripheral blood</< li>