T & B Cell Gene Rearrangements

• Objective: To aid in the diagnosis of T and B cell lymphoproliferative disorders
• Description: Detect gene rearrangements of the T-cell receptor Gamma (TRG), T-cell receptor Beta (TRB), B-cell immunoglobulin heavy chain (IGH), and B-cell immunoglobulin light chain kappa (IGK) genes to determine the clonality of T or B cells
• Performing Lab: Molecular Pathology
  Direct inquiries to Dr. David Y. Zhang (212)-659-8173
• Specimen requirements: One (1) lavender top (EDTA) tube (4ml) from peripheral blood or bone marrow aspirate or one (1) paraffin-embedded tissue block

JAK2 Mutation

• Objective: To aid in the diagnosis of myeloproliferative disease.
• Description: Detect a mutation in the Janus kinase 2 (JAK2) gene located in exon 14 (V617F) that has been associated with polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF)
• Performing Lab: Molecular Pathology
  Direct inquiries to Dr. David Y. Zhang (212)-659-8173
• Specimen requirements: One (1) lavender top (EDTA) tube (4ml) from peripheral blood

bcr-abl

• Objective: To therapeutically monitor patients with chronic myelogenous leukemia (CML)
• Description: Quantitate bcr/abl fusion transcripts (b3a2, b2a2 and e1a2) caused by the t(9;22) translocation to assess therapy efficacy and monitor minimal residual disease
• Performing Lab: Molecular Pathology
  Direct inquiries to Dr. David Y. Zhang (212-659-8173)
• Specimen requirements: One (1) lavender top (EDTA) tube (4ml) from peripheral blood or bone marrow aspirate or one (1) paraffin-embedded tissue block

Conventional and Molecular Cytogenetics (FISH) Hematological Malignancies

• Objective: To evaluate prognosis and aid in the selection of appropriate treatment in specific types of leukemia
• Description: Examine specific chromosomal and/or gene abnormalities associated with specific types of leukemia
• Performing Lab: Tumor Cytogenics
  Direct inquiries to Dr. Vesna Naifeld (212) 241-8801
• Specimen requirements: Paraffin-embedded Brain Biopsy

Molecular Cytogenetics (FISH)

• Objective: For evaluation of brain cancer, specifically glioma with favorable prognosis Description: Examine the presence of co-deletion of 1p and 19q in patients with glioma using four different chromosomal regions
• Performing Lab: Tumor Cytogenetics
  Direct inquires to Dr. Vesna Najfeld (212) 241-8801
• Specimen requirments: Paraffin-embedded Brain Biopsy