Gene Therapy and Brain Tumor Laboratory

Gold Divider 4Col

Peer Reviewed Articles

  1. Uzzaman M, Keller G, I Germano. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology (2008 in Press)
  2. Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008.
  3. Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant gliomas. Cancer Biology and Therapy 7:81-7, 2008.
  4. Uzzaman M, Keller G, Germano IM. Enhanced pro-apotptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651,2007.
  5. Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006.
  6. Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005.
  7. Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005.
  8. Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005.
  9. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005.
  10. Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004.

Books

  1. Malignant Gliomas. Isabelle M. Germano (editor), Neurosurgical Focus Vol 14, AANS Charlottesville, VA, February 2003.
  2. Advanced Techniques in Image-guided Neurosurgery. Isabelle M Germano (editor), Thieme Publishers, NY, 2002.
  3. Advances in Neurosurgical Treatment of Functional Disorders. Isabelle M Germano (editor), Seminars in Neurosurgery, Volume 12, Thieme, NY, 2001.
  4. LINAC and Gammaknife Neurosurgery. Isabelle M Germano (editor), AANS Publications Committee, Park Ridge, IL, 2000.
  5. Neurosurgical Treatment of Movement Disorders. Isabelle M Germano (editor), AANS Publications Committee, Park Ridge, IL, 1998.

Book Chapters

  1. Germano IM and Weisz D. Computer technology as an adjuvant for target location and validation. In: Microelectrode Recording in Movement Disorder, Kim Burchiel (ed), Thieme Publisher, NY 2004 pp152-163.
  2. Sperber ES, Moshé SL, Germano IM. Do effects of FS differ in normal vs. abnormal brain? In: Baram TZ and Shinnar S (eds). Febrile Seizures. Academic Press, 2002, pp139-151.
  3. Germano IM and Bucholz RD. Historical remarks. In: Germano IM (ed) Advanced techniques in image-guided Neurosurgery, Thieme Publisher, NY 2001, pp 1-10.
  4. Germano IM and Deutch H. The optical digitizer. In: Germano IM (ed) Advanced techniques in image-guided Neurosurgery, Thieme Publisher, NY 2001, pp 1-10.
  5. Germano IM and Kondo S. Image-guided tumor resection. In: Germano IM (ed) Advanced techniques in image-guided Neurosurgery, Thieme Publisher, NY 2001, pp 1-10.
  6. Germano IM, Villalobos H, Mandell L. LINAC for brain metastasis. In: Germano IM (ed.), Radiosurgery. AANS Publication Committee, Park Ridge, IL, pp177-188, 1999.
  7. Schwartz A and Germano IM. Stereotactic biopsy: Indications and Technique. In: Hall WA and McCutcheon IE (eds.), Infections in Neurosurgery. AANS Publication Committee, Park Ridge, IL, pp177-188,1999.
  8. Sperber EF, Germano IM, Friedman LK, Romero MT. The Resiliency of the Immature Brain to Seizure Induced Damage. In: Nehlig A, Motte J (eds.) Childhood Epilepsies and Brain Development. John Libbey and Co., London, pp. 255-262, 1999.
  9. Germano IM and Heilbrun P. Interactive computer-assisted image-guided technology as an adjuvant to neurosurgery for movement disorders. In: Germano IM (ed), Neurosurgical treatment of movement disorders. AANS Publication Committee, Park Ridge, IL, pp 219-226, 1998.
  10. Germano IM, Sperber EF, Moshe SL. Experimental aspects of neuronal migration disorders in the juvenile brain. In: Tuxorn I, Holthausen H, Boenigk (eds). Pediatric epilepsy syndromes and their surgical treatment. J. Libbey & Co, London, pp 111-116, 1997.

Abstracts

  1. Germano IM. Radiosurgery: What the literature supports. Congress of Neurological Surgeons, Orlando, September 20-25, 2008.
  2. Uzzaman M, Keller G, Germano IM. Embryonic stem cell (ESC)-derived astrocytes expressing melanoma differentiation associated gene-7 (mda-7/IL-24) selectively induce growth suppression, apoptosis, and radiosensitization in malignant gliomas. Neuro-Oncology, 9: 598, 2007.
  3. Germano IM. Pre-operative and intraoperative brain mapping, for tumor surgery and epilepsy. American Association of Neurological Surgeons, Washington, DC, April 14-19, 2007.
  4. Germano IM. Controversies in Neurosurgery: Vestibular Schwannomas: Radiosurgery versus Surgery, Moderator, American Association of Neurological Surgeons, Washington, DC, April 14-19, 2007.
  5. Germano IM. Update on tumor surgery. American Association of Neurological Surgeons, Washington, DC, April 14-19, 2007.
  6. Uzzaman M, Keller G, Germano IM. In vivo gene therapy for malignant glioma: Use of Embryonic Stem Cell derived astrocytes expressing tumor necrosis factor related apoptosis inducing ligand (TRAIL). Neuro-Oncology, 8: 418, 2006.
  7. Germano IM. Functional mapping of cerebral cortex; advantages and limitations. Moderator Breakfast Seminar, American Association of Neurological Surgeons, San Francisco, April 22-27, 2006.
  8. Germano IM. Operating in Eloquent Cortex. Practical Clinic, Faculty, Congress of Neurological Surgeons, Boston, October 8-13, 2005.
  9. Germano IM. Update on brain tumor surgery. Moderator, Symposium, American Association of Neurological Surgeons, San Francisco, April 22-27, 2006.
  10. Germano IM. Temozolomide as a targeted therapy for glioblastoma. New insights and predictive value of MGMT silencing. Discussant, Plenary Session, American Association of Neurological Surgeons, New Orleans, April 16-21, 2004.
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