Dr. Chao is interested in exploration and development of gene therapy for genetic diseases using recombinant adeno-associated virus (AAV) vectors. Current research in Dr. Chao's lab is focusing on two fronts:

1. To investigate mechanisms underlying host immunity and tolerance to FVIII and FIX following AAV-based gene transfer.
2. To develop spliceosome-mediated RNA trans-splicing mediated RNA repair for gene therapy of Duchene Muscular Dystrophy using AAV as the delivery vector.