Publications on PubMed
Lu Y, Gong P, Cederbaum AI. Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency. Toxicology. 2008 Oct 30;252(1-3):9-16.
Wang X, Cederbaum AI. S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Arch Biochem Biophys. 2008 Sep 1;477(1):1-11.
Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology. 2008 May;47(5):1483-94.
Wu D, Cederbaum AI. Development and Properties of HepG2 Cells That Constitutively Express CYP2E1. Methods Mol Biol. 2008;447:137-50.
Lu Y, Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med. 2008 Mar 1;44(5):723-38.
Jimenez-Lopez JM, Wu D, Cederbaum AI. Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells. Toxicol In Vitro. 2008 Feb;22(1):106-15.
Zhuge J, Cederbaum AI. Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Arch Biochem Biophys. 2007 Oct 15;466(2):177-85.
Dey A, Cederbaum AI. Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology. 2007 Jun;45(6):1355-65.
Kessova IG, Cederbaum AI. Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic Biol Med. 2007 May 15;42(10):1470-80.
Dey A, Caro AA, Cederbaum AI. S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G91-103.
Dey A, Cederbaum AI. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. Arch Biochem Biophys. 2007 May 15;461(2):275-86.
Wang X, Cederbaum AI. Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med. 2007 Apr 1;42(7):971-84.
Caro AA, Cederbaum AI. Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1. Arch Biochem Biophys. 2007 Jan 15;457(2):252-63.
Bai J, Cederbaum AI. Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels. J Pharmacol Exp Ther. 2006 Dec;319(3):1435-43.
Zhuge J, Cederbaum AI. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1. Free Radic Biol Med. 2006 Oct 1;41(7):1100-12.
Cederbaum AI. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S22-5.
Cederbaum AI. CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med. 2006 Jul;73(4):657-72.
Jimenez-Lopez JM, Cederbaum AI. CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):671-85.
Lu Y, Cederbaum AI. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatology. 2006 Jul;44(1):263-74.
Caro AA, Cederbaum AI. Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity. J Pharmacol Exp Ther. 2006 Jul;318(1):360-72.
Gong P, Cederbaum AI. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem. 2006 May 26;281(21):14573-9.
Bai J, Cederbaum AI. Adenovirus-Mediated Expression of CYP2E1 Produces Liver Toxicity in Mice. Toxicol Sci. 2006 Jun;91(2):365-71.
Dey A, Cederbaum AI. Geldanamycin, an Inhibitor of Hsp90, Potentiates Cytochrome P4502E1-Mediated Toxicity in HepG2 Cells. J Pharmacol Exp Ther. 2006 Jun;317(3):1391-9.
Gong P, Cederbaum AI. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem. 2006 May 26;281(21):14573-9.
Wang X, Cederbaum AI. S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. J Pharmacol Exp Ther. 2006 Apr;317(1):44-52.
Wu D, Cederbaum AI. Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells. Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G674-84.
Dey A, Kessova IG, Cederbaum AI. Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1. Arch Biochem Biophys. 2006 Mar 15;447(2):155-66.
Bai J, Cederbaum AI. Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. J Biol Chem. 2006 Feb 24;281(8):5128-36.
Caro AA, Cederbaum AI. Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity. Free Radic Biol Med. 2006 Feb 1;40(3):364-75.
Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology. 2006 Feb;43(2 Suppl 1):S63-74.
Lu Y, Cederbaum AI. Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicol Sci. 2006 Feb;89(2):515-23.
Gong P, Cederbaum AI. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology. 2006 Jan;43(1):144-53.
Zhuge J, Cederbaum AI. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med. 2006 Jan 1;40(1):63-74.
Kessova IG, Cederbaum AI. The Effect of CYP2E1-Dependent Oxidant Stress on Activity of Proteasomes in HepG2 Cells. J Pharmacol Exp Ther. 2005 Oct;315(1):304-12.
Nieto N, Cederbaum AI. S-adenosylmethionine blocks collagen I production by preventing TGFbeta induction of the COL1A2 promoter. J Biol Chem. 2005 Sep 2;280(35):30963-74.
Wu D, Cederbaum AI. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):70-6.
Lu Y, Wang X, Cederbaum AI. Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole. Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G308-19.
Wang X, Lu Y, Cederbaum AI. Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology. 2005 Aug;42(2):400-10.
Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93.
Jimenez-Lopez JM, Cederbaum AI. Protein Kinase C Signaling as a Survival Pathway Against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells. J Pharmacol Exp Ther 2005 Mar; 312(3):998-1006.
Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005 Jan; 19(1):136-38.
Wu D, Cederbaum AI. Glutathione Depletion in CYP2E1 Expressing Liver Cells Induces Toxicity due to the Activation of p38 MAP Kinase and Reduction of NF-kB DNA Binding Activity. Mol Pharmacol. 2004 Sep;66(3):749-60.
Pan M, Cederbaum AI, Zhang YL, Ginsberg HN, Williams KJ, Fisher EA. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest. 2004 May;113(9):1277-87.
Caro AA, Cederbaum AI. Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations. Free Radic Biol Med. 2004 May 15;36(10):1303-16.
Jimenez-Lopez JM, Cederbaum AI. Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity. Free Radic Biol Med. 2004 Feb 1;36(3):359-70.
Gong P, Cederbaum AI, Nieto N. Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Free Radic Biol Med. 2004 Feb 1;36(3):307-18.
Gong P, Cederbaum AI, Nieto N. The Liver-selective NO-donor V-PYRRO/NO protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Mol Pharmacol 2004 Jan;65(1):130-138.
Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004;44:27-42.
Carmiel-Haggai M, Cederbaum AI, Nieto N. Binge ethanol exposure increases liver injury in obese rats. Gastroenterology. 2003 Dec;125(6):1818-1833.
Perez MJ, Cederbaum AI. Adenovirus-mediated expression of Cu/Zn- or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity. Hepatology. 2003 Nov;38(5):1146-1158.
Kessova IG, Ho YS, Thung S, Cederbaum AI. Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Hepatology. 2003 Nov;38(5):1136-1145.
Kessova I, Cederbaum AI. CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Curr Mol Med. 2003 Sep;3(6):509-18.
Gong P, Cederbaum AI, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem. 2003 Aug 8;278(32):29693-29700.
Caro AA, Cederbaum AI. Role of phospholipase A 2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Jun;278(36):33866-33877.
Perez MJ, Cederbaum AI. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology. 2003 Jun;37(6):1395-1404.
Nieto N, Cederbaum AI. Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. J Biol Chem. 2003 April 25;278(17):15360-15372.
Bai JX, Cederbaum AI. Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53. J Biol Chem. 2003 Feb 14;278(7):4660-4667.
Nieto N, Mari M, Cederbaum AI. Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Hepatology. 2003 Jan;37(1):96-106.
Wu D, Cederbaum AI. Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. J Biol Chem. 2003 Jan 10;278(2):1115-1124.
Wu D, Cederbaum AI. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. Hepatology. 2002 Jun;35(6):1420-1430.
Nieto N, Friedman SL, Cederbaum AI. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem. 2002 Mar 22;277(12):9853-9864.
Caro AA, Cederbaum AI. Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2002 Jan;277(1):104-113.
Bai JX, Cederbaum AI. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P4502E1-dependent toxicity in HepG2 cells. J Biol Chem. 2001 Feb 9;276:4315-4321.
