Benjamin K. Chen Laboratory

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Recognition and Publications

Wolfgang Hübner, Ping Chen, Armando Delportillo, Yuxin Liu, Ronald Gordon, Benjamin K. Chen. Sequence of HIV-1 Gag localization and oligomerization monitored with continuous, live confocal imaging of a replication-competent, fluorescently tagged HIV-1. Journal of Virology, In press. 2007.

Ping Chen, Wolfgang Hübner, Matthew Spinelli, Benjamin K. Chen. Predominant mode of HIV transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of Virology, In press. 2007.

Wolfgang Hübner, Benjamin K. Chen. Inhibition of viral assembly in murine cells by HIV-1 matrix. Virology 351: 27-38.  2006.

Ping Chen, Kareen Riviere, Wolfgang Hübner, Yu-Xin Liu, Benjamin K. Chen. Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell type dependent manner in human T cells. Virology 349:1-12 2006. 

Benjamin K. Chen, Itay Rousso, Sung Shim, Peter S. Kim. Efficient assembly of an HIV/MLV Gag-chimeric virus in murine cells. Proceedings of the National Academy of Sciences, U S A. 98: 15239-15244. 2001.

Itay Rousso, Mark B. Mixon, Benjamin K. Chen, Peter S. Kim. Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proceedings of the National Academy of Sciences, U S A. 97:13523-13525. 2000.

George B. Cohen, Vangipuram S. Rangan, Benjamin K. Chen, Stuart Smith, and David Baltimore. The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation. Journal of Biological Chemistry 275:23097-23105. 2000. 

George B. Cohen, Rajesh T. Gandhi, Daniel M. Davis, Ofer Mandelboim, Benjamin K. Chen, Jack L. Strominger, and David Baltimore. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity. 10:661-671. 1999.

Shigemi Kinoshita, Benjamin K. Chen, Hideto Kaneshima, and Garry P. Nolan. Host control of HIV-1 parisitism in T cells by the nuclear factor of activated T cells. Cell. 95:595-604. 1998. 

Rajesh T. Gandhi, Benjamin K. Chen, and David Baltimore. Human immunodeficiency virus type 1 directly kills T cells by a Fas-independent mechanism. Journal of Experimental Medicine. 187:1113-1122. 1998.

Kathleen L. Collins, Benjamin K. Chen, Spyros A. Kalams, Bruce D. Walker, and David Baltimore. HIV-1 Nef protein protects infected primary human cells from killing by cytotoxic T lymphocytes. Nature. 391: 397-401. 1998.

Benjamin K. Chen, Mark B. Feinberg, and David Baltimore. The a B sites in the human immunodeficiency virus-1 long terminal repeat enhance virus replication yet are not absolutely required for viral growth. Journal of Virology. 71:5495-5504. 1997.

Linqi Zhang, Yaoxing Huang, Hannah Yuan, Benjamin K. Chen, James Ip, and David D. Ho. Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection. Journal of Virology. 71:5608-5613. 1997.

Linqi Zhang, Yaoxing Huang, Hannah Yuan, Benjamin K. Chen, James Ip, and David D. Ho. Identification of a replication-competent pathogenic human immunodeficiency virus type 1 with a duplication in the TCF-1A region but lacking NF-KB binding sites. Journal of Virology. 71:1651-1656. 1997.

Benjamin K. Chen, Rajesh Gandhi, and David Baltimore. CD4 down-modulation during infection of human T cells with HIV-1 involves independent activities of vpu, env, and nef. Journal of Virology. 70:6044-6053. 1996.

Robert H. Rubin, David Baltimore, Benjamin K. Chen, Robert A. Wilkinson, Alan J. Fischman. In vivo tissue distribution of CD4 lymphocytes in mice determined by radioimmunoscintigraphy with an 111In-labeled anti-CD4 monoclonal antibody. Proceedings of the National Academy of Sciences, USA. 93:7460-7463. 1996.

Ruth I. Conner, Benjamin K. Chen, Sunny Choe, and Nathaniel R. Landau. Vpr is required for efficient replication of human immunodeficiency virus type-1 in Mononuclear Phagocytes. Virology. 206:935-944. 1995.

Benjamin K. Chen, Kalle Saksela, Raul Andino, and David Baltimore. Distinct modes of human immunodeficiency virus-1 proviral latency revealed by superinfection of non-productively infected cell lines with recombinant luciferase-encoding viruses. Journal of Virology. 68:654-660. 1994.

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