Gender	Female
E-mail	mary.klotman@mssm.edu
Awards	Irene and Dr. Arthur M. Fishberg Professor of Medicine (Infectious Diseases)
	2005 Association of American Physicians Elected to the Association of American Physicians
	2001 Mt. Sinai School of Medicine Faculty Achievement Award for Outstanding Clinical Research

Dr. Klotman is Chief of the Division of Infectious Diseases and Director of the Global Health & Emerging Pathogens Institute.

In the News

Dr. Klotman discusses how the elderly and the very young can be protected against the mosquito borne West Nile virus in The Daily News feature "The Daily Check Up." View the PDF.

Mary E. Klotman, MD, Co-Director of Mount Sinai's Global Health and Emerging Pathogens Institute, and Panthera, an organization dedicated to the conservation of wild cats, are now collaborating to improve health care for underserved populations while protecting animals and their habitats.  Find out more in Inside Mount Sinai.

The primary focus of Dr. Klotman's laboratory is the molecular pathogenesis and therapy of Human Immunodeficiency Virus 1 (HIV-1) infection. Ongoing molecular pathogenesis studies include establishing the role of virus and host factors in determining disease progression in HIV-1 infection. One of the project studies the role of viral proteins in HIV-associated nephropathy as part of a multi-project NIH-funded initiative to understand the cell biology, virology and genetically determined host factors involved in this devastating manifestation of HIV. Recent important observations made by this group include the demonstration that HIV resides in and evolves separately in kidney cells and that anti-retroviral therapy can relieve some of the clinical manifestations related to HIV-associated nephropathy but the virus persists at that site despite therapy. Additional projects include elucidation of the relationship between innate immune mediators and HIV, particularly as part of the complex interaction between other sexually transmitted diseases and HIV. Ongoing work on this project includes the isolation and characterization of active HIV-1 inhibitory protein(s) derived from CD8+ cells and determining the role and mechanism of action of host antimicrobial peptides and toll-like receptor activation in suppressing and/or inducing HIV. These projects have both a basic science component focused on understanding the complex interactions between HIV and the vaginal and cervical mucosa that facilitate viral entry in the setting of other sexually transmitted diseases as well as a focus on understanding local immune responses that might be altered by candidate topical microbicides under development to prevent transmission.

 

 

Teleshova N, Chang T, Profy A, Klotman ME. Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer. Antimicrob Agents Chemother May 2008; 52(5): 1751-1758.

Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL. Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: Role in enhanced transmission. J Immunol 2008 May; 180(9): 6176-6185.

Mosoian A, Teixeira A, High AA, Christian RE, Hunt DF, Shabanowitz J, Liu X, Klotman M. Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages. J Virol 2006 September; 80(18): 9200-9206.

Liu X, Mosoian A, Chang TL, Zerhouni-Layachi B, Snyder A, Jarvis GA, Klotman ME. Gonococcal Lipooligosaccharide Suppresses HIV Infection in Human Primary Macrophages through Induction of Innate Immunity. J Infect Dis 2006 September; 194(6): 751-759.

Chang TL, Klotman ME. Defensins in innate antiviral immunity. Nat Rev Immunol 2006 June; 6(6): 447-456.

Ross MJ, Fan C, Ross MD, Chu TH, Shi Y, Kaufman L, Zhang W, Klotman ME, Klotman PE. HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. J Acquir Immune Defic Syndr 2006 May; 42(1): 1-11.

Ross MJ, Wosnitzer MS, Ross MD, Granelli B, Gusella GL, Husain M, Kaufman L, Vasievich M, D'Agati VD, Wilson PD, Klotman ME, Klotman PE. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. J Am Soc Nephrol 2006 April; 17(4): 996-1004.

Wyatt C, Arons RR, Klotman PK, Klotman ME. Acute renal failure in hospitalized patients with HIV: Risk. AIDS 2006 February; 20(4): 561-565.

Chang TL, Vargas J, Delportillo A, Klotman ME. Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J Clin Invest 2005 March; 115(3): 765-773.

Ross MD, Bruggeman LA, Hanss B, Sunamoto M, Marras D, Klotman ME, Klotman PE. Podocan; a novel small leucine-rich repeat protein expressed in the Sclerotic glomerular lesion of experimental HIV-associated nephropathy. J Biol Chem 2003 June;.

Chang TL, Francois F, Mosoian A, Klotman M. CAF-Mediated Human Immunodeficiency Virus (HIV) Type 1 transcriptional inhibition is distinct from Defensin-1 HIV inhibition. J Virol 2003 June; 77(12): 6777-6784.

Francois F, Klotman ME. PI3-Kinase Regulates Human Immunodeficiency Virus Type I (HIV-1) replication following Viral entry in primary CD4+ T lymphocytes and macrophages. J. Virol 2003 February; 77(4): 2539-2549.

Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D'Agati VD, Hahn BH, Klotman M, Klotman PE. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med 2002 May; 8(5): 522-526.

Chang TL, Mosoian A, Pine R, Klotman ME, Moore JP. A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. J Virol 2002 Jan; 76(2): 569-81.

Herold BC, Schordi-Bello I, Cheshenko N, Marcellino D, Dzuzelewski M, Francoisf F, Morin R, Mascasullo V, Anderson RA, Chaney Ii C, Waller DP, Zaneveld LJ D, Klotman ME. Mandelic acid condensation polymer: novel candidate microbicide for prevention of Human Immunodeficiency Virus and Herpes Simplex virus entry. J Virol 2002 November; 76(22): 11236-11244.

Cara A, Vargas J Jr, Keller M, Jones S, Mosoian A, Gurtman A, Cohen A, Parkas V, Wallach F, Chusid E, Gelman IH, Klotman ME. Circular viral DNA and anomalous junction sequence in PBMC of HIV-infected individuals with no detectable plasma HIV RNA. Virology 2002 Jan 5; 292(1): 1-5.

Winston JA, Bruggeman LA, Ross MD, Jacobson J, Ross L, D'Agati DV, Klotman PE, Klotman ME. Associated Nephropathy During Primary Infection, Establishment of a Renal Reservoir. N Engl J Med 2001 Jun 28; 344(26): 1979-84.

Schecter AD, Berman AB, Yi L, Mosoian A, McManus CM, Berman JW, Klotman M, Taubman MB. HIV envelope gp120 activates human arterial smooth muscle cells. Proc Natl Acad Sci USA 2001 Aug 28; 98(18): 10142-7.

Winston JA, Bruggeman LA, Ross MD, Jacobson J, Ross L, D'Agati VD, Klotman PE, Klotman ME. Nephropathy and establishment of a renal reservoir of HIV Type 1 during primary infection. N Engl J Med 2001 June; 344: 1979-1984.

Mosoian A, Teixeira A, Caron E, Piwoz J, Klotman ME. CD8+ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from beta-chemokines. Viral Immunol 2000; 13(4): 481-95.

Jacobson J, Lowy I, Fletcher CV, O'Neill TJ, Tran DN, Ketas TJ, Trkola A, Klotman M, Maddon PJ, Olson WC, Israel RJ. Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults. J Infect Dis 2000 Jul; 182(1): 326-9.

Tellier MC, Greco G, Klotman M, Mosoian A, Cara A, Arap W, Ruoslahti E, Pasqualini R, Schnapp L. Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. J Immunol 2000 Mar 15; 164(6): 3236-45.